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Cancer

Relay Therapeutics presents new ERα degraders

Jan. 24, 2024
Relay Therapeutics Inc. has divulged proteolysis targeting chimeric (PROTAC) compounds comprising an E3 ubiquitin ligase binding moiety covalently linked to an estrogen receptor α (ERα; ESR1)-targeting moiety.
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Cancer

Bayer describes new TEAD inhibitors for cancer

Jan. 24, 2024
Bayer AG has identified transcriptional enhancer factor (TEAD) inhibitors reported to be useful for the treatment of cancer.
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Cancer

Hansoh researchers divulge new FGFR inhibitors

Jan. 24, 2024
Jiangsu Hansoh Pharmaceutical Group Co. Ltd. and Shanghai Hansoh Biomedical Co. Ltd. have synthesized fibroblast growth factor receptor (FGFR) inhibitors reported to be useful for the treatment of cancer and achondroplasia.
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Neurology/Psychiatric

Amyloid Solution patents new MAPT and Aβ aggregation inhibitors for Alzheimer’s disease

Jan. 24, 2024
Amyloid Solution Inc. has disclosed microtubule-associated protein tau (PHF-tau; MAPT) and/or...
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Drug R&D concept image.
Endocrine/Metabolic

Discovery of novel positive allosteric modulators of NAMPT

Jan. 24, 2024
Novel nicotinamide phosphoribosyltransferase (NAMPT) positive allosteric modulators (N-PAMs) have been discovered and evaluated by University of Illinois and University of Arizona investigators.
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Acute myeloid leukemia
Cancer

Novel FLT3 PROTAC degrader active in leukemia models

Jan. 24, 2024
One-third of patients with acute myeloid leukemia (AML) present mutations in the FMS-like tyrosine kinase 3 (FLT3) gene. Several first- and next-generation FLT3 inhibitors are currently being used in AML management, but there is a need for new options able to achieve complete and sustained FLT3 signaling suppression.
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Illustration of Trypanosoma cruzi parasite in the bloodstream
Infection

PTR1 inhibitors based on aryl-2-nitroethyl triamino-pyrimidines as promising anti-Trypanosoma agents

Jan. 24, 2024
To combat trypanosomiasis and leishmaniasis, researchers from the University of Modena and Reggio Emilia and collaborators conducted a study focusing on pteridine reductase 1 (PTR1), a catalytic protein crucial to the folate metabolic pathway in Trypanosomatid parasites.
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Immuno-oncology

Harbour’s bispecific antibody HBM-9027 cleared to enter clinic in US for solid tumors

Jan. 24, 2024
Harbour Biomed Ltd. has obtained FDA clearance of its IND application to initiate a first-in-human...
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Neurology/Psychiatric

Vanda receives IND clearance for ASO for Charcot-Marie-Tooth disease type 2S

Jan. 24, 2024
Vanda Pharmaceuticals Inc. has announced FDA approval of its IND application to evaluate VCA...
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Tree in the shape of human head losing leaves
Neurology/Psychiatric

Psilera selects behavioral variant frontotemporal dementia as lead indication for PSIL-006

Jan. 24, 2024
Psilera Inc. has selected behavioral variant frontotemporal dementia (FTD) as the lead...
Read More
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