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Home » Topics » Science » Biomarkers

Biomarkers
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Cancer cell in the cross-hairs
Cancer

Pan-cancer proteome atlas reveals new biomarkers and targets

June 3, 2025
By Mar de Miguel
No Comments
An international group of scientists has completed the first draft of The Pan-Cancer Proteome Atlas (TPCPA). The project is based on mass spectrometry of 22 cancer types, which has identified more than 9,000 proteins from 1,000 tumors. The results reveal which proteins allow for the classification of different cancer types, biomarkers and potential therapeutic targets, which are now available to the entire scientific community.
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Lung cancer illustration
Cancer

Long noncoding RNA OIP5-AS1 inhibits lung cancer progression in preclinical studies

June 2, 2025
No Comments
The polarization of macrophages is crucial in modulating the tumor microenvironment and impacting cancer development. Long noncoding RNAs (lncRNAs) have been identified as key regulators in this process.
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Illustration of tumor in the liver
Biomarkers

DNAJC7 involved in hepatocellular carcinoma progression and prognosis

May 30, 2025
No Comments
Hepatocellular carcinoma (HCC) is among the leading causes of cancer-related deaths worldwide due to lack of effective diagnosis at early stages and limited comprehension of its pathogenesis, thus limiting the development of effective treatments.
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Illustration of cancer in the bile ducts
Biomarkers

KMT9 has prognostic impact on cholangiocarcinoma

May 28, 2025
No Comments
Cholangiocarcinoma is a rare cancer that arises from the intrahepatic biliary epithelium or extrahepatic bile ducts. Apart from genetic mutations, epigenetic changes are also contributing to cancer development, making DNA methylation and histone modification focus for cancer research.
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Sore throat illustration
Cancer

Study identifies C16orf74 as prognostic biomarker in head and neck cancer

May 27, 2025
No Comments
Head and neck squamous cell carcinoma (HNSCC), which makes up the majority of head and neck cancers, is an aggressive disease with a poor prognosis despite current multimodal treatments. Its progression is strongly linked to immune evasion and impaired immune signaling, highlighting the urgent need for new diagnostic and prognostic biomarkers to improve patient outcomes.
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Lungs and bronchiole
Biomarkers

NEIL2 downregulation worsens COPD symptoms, study finds

May 26, 2025
No Comments
Researchers from the U.S. have published findings regarding the link between low NEIL2 expression and airway inflammation and increased DNA damage.
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Conceptual image for brain cancer treatment
Biomarkers

miR-1290 predicts seizure susceptibility in glioblastoma patients

May 21, 2025
No Comments
Glioblastoma (GBM) is an aggressive cancer from the CNS usually characterized by a very bad prognosis. It is known that around 30%-35% of patients with GBM develop epilepsy as a comorbidity of the disease.
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Immuno-oncology

Targeting B4GALT5 to boost tumor antigen display in pancreatic ductal adenocarcinoma

May 19, 2025
No Comments
Pancreatic ductal adenocarcinoma (PDAC) accounts for more than 90% of cases of pancreatic cancer, and prognosis for PDAC remains poor despite treatment advances. One reason is that PDAC downregulates the display of antigens on the surface of tumor cells, helping it evade the patient’s immune system and therapies involving immune checkpoint inhibitors.
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Photomicrograph of hepatocellular carcinoma
Cancer

RGS14: An endogenous inhibitor of G protein-coupled receptors that promotes hepatocellular carcinoma

May 16, 2025
No Comments
Hepatocellular carcinoma (HCC), which accounts for up to 80% of cases of primary liver cancer, is typically diagnosed in an advanced stage, meaning a poor prognosis. Understanding what drives progression may help identify proteins and pathways that can be targeted to slow down the disease.
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Biomarkers

GPR171 is a prognostic marker in cervical cancer

May 14, 2025
No Comments
Recent evidence has shown that G protein-coupled receptor 171 (GPR171) may be a key T-cell checkpoint in tumor immunity.
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