Increasing evidence exists suggesting plasma exosomal microRNAs (miRNAs) are involved in tumor progression, but their role in breast cancer is still unknown. Plasma exosome miRNA sequencing revealed that elevated levels of miR-361-3p were significantly correlated with malignant breast cancer progression in patients.
There is increasing interest in studying exosome molecules, and particularly long non-coding RNAs (lncRNAs), in the diagnosis of gastric cancer. Microarray analysis was performed from samples obtained from patients with gastric cancer who underwent endoscopic resection.
Researchers from China have elucidated the prognostic role of aberrant expression of RNA binding motif protein, X chromosome (RBMX) in several cancer types using samples from cancer patients.
N-acetyltransferase 10 (NAT10) is an RNA cytidine acetyltransferase involved in multiple biological processes, such as inflammatory responses or osteogenic differentiation, and linked to pathological states such as asthma, viral infections, cancer, or laminopathies.
Prune belly syndrome (PBS), also known as Eagle-Barrett syndrome, is a rare multisystemic congenital myopathy that mainly affects males, and which is incompletely understood genetically speaking.
There is a strong relationship between heart failure (HF) and atrial fibrillation (AF): half of the patients with HF acquire AF. Recent studies discovered a genetic basis underlying AF, which demonstrated a strong heritable component to this disease.
Pulmonary arterial hypertension (PAH), characterized by vasoconstriction and pulmonary vascular remodeling, has a 10% annual mortality rate among patients due to right heart failure. There are genetic variants known to impact the risk of PAH, but susceptibility from epigenetic changes is poorly understood.
Radiotherapy resistance and metastasis are among the top risk factors for refractory oral squamous cell carcinoma (OSCC), the mechanisms of which must be elucidated, plus there is a lack of biomarkers to predict response.
From previous reports, there is evidence that cancer cells overexpress inositol 1,4,5-trisphosphate receptor-interacting protein-like 1 (ITPRIPL1) to evade the immune system and promote tumor growth. Tissue samples from patients with non-small-cell lung cancer (NSCLC) were collected and used for studying the expression (intensity and extent) patterns of ITPRIPL1 and its diagnostic and prognostic value in this cancer type.
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