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Home » Topics » Science » Drug design, drug delivery and technologies

Drug design, drug delivery and technologies
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3D illustration of a chain of amino acid or biomolecules called protein
Drug design, drug delivery & technologies

Alphadesign: AI creating proteins from scratch

June 19, 2025
By Nuala Moran
No Comments
The Alphafold machine learning system for predicting a protein’s structure from its amino acid sequence has been adapted to make it possible to design de novo proteins that fold in a particular way and bind to prespecified target proteins. The sister system, called Alphadesign, works by generating random strings of amino acids, using Alphafold to predict their structure, and then iteratively optimizing the design.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 18, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos.
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Ernst Haeckel's 1874 drawings of embryonic development.
Cardiovascular

A human heart developed in a pig embryo over 21 days

June 17, 2025
By Mar de Miguel
No Comments
Chinese researchers are preparing the details for the publication of another scientific milestone, the creation of a chimera with a human heart and a kidney developed from human stem cells in pig embryos. These studies aim to address the shortage of immunocompatible organ donors while shedding light on some of the most fundamental questions in developmental biology.
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Drug discovery illustration
Immune

CSPC and Astrazeneca establish strategic research collaboration

June 16, 2025
No Comments
CSPC Pharmaceutical Group Ltd. has entered into a strategic research collaboration agreement with Astrazeneca plc for the discovery and development of novel oral small-molecule candidates utilizing the group’s AI-driven, dual-engine efficient drug discovery platform.
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microfluidic patch pump
Patents

Researchers file patent for microfluidic patch-pump drug delivery platform

June 12, 2025
By Simon Kerton
Researchers from Virginia Polytechnic Institute and State University filed for protection of their development of a slim, painless, and affordable microfluidic infusion pump device for the continuous transdermal delivery of drugs.
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Vaxxas HD-MAP administration

Microneedles could solve vaccine distribution challenges

June 10, 2025
By Tamra Sami
Microneedle technology could help simplify vaccine delivery to better support global immunization efforts, and Australia is leading the way in this innovative technology.
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Digital rendering of molecular structures
Drug design, drug delivery & technologies

Open-source AI model can predict small-molecule binding affinity

June 10, 2025
By Anette Breindl
No Comments
Researchers at the Massachusetts Institute of Technology and Recursion Pharmaceuticals Inc. have released an open-source AI model that can predict the binding strength of small molecules as well as structures of proteins and biomolecular complexes. The model, which is called Boltz-2 and was released by the research team on the developer platform Github on June 6, addresses a major bottleneck in drug discovery with its improved ability to predict binding strengths.
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Vaxxas HD-MAP administration

Microneedles could solve vaccine distribution challenges

June 6, 2025
By Tamra Sami
Microneedle technology could help simplify vaccine delivery to better support global immunization efforts, and Australia is leading the way in this innovative technology.
Read More
Signify Daniel-Siegwart and RA Session II
Drug design, drug delivery & technologies

Signify Bio’s $15M round advances in situ protein therapeutics

June 6, 2025
By Karen Carey
No Comments
Turning the human body into a biofactory of precision protein therapeutics is the focus of newly launched Signify Bio, which emerged with an oversubscribed $15 million initial financing to advance three platforms with broad potential across therapeutic areas.
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Illustration of brain receptors with their neurotransmitters
Neurology/psychiatric

New GluN1/GluN3A NMDA receptor inhibitors based on AI

June 6, 2025
No Comments

Scientists at Shanghai Tech University have used the scaffold-hopping artificial intelligence model Geminimol to identify N-methyl-D-aspartate (NMDA) receptor ligands that show selectivity and specificity. The researchers found that GM-10 could be a potent inhibitor of the GluN1/GluN3A subunits of the NMDA receptor, demonstrating the utility of this technique to develop new drugs.


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