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BioWorld - Monday, December 11, 2023
Home » Topics » Drug design, drug delivery and technologies, BioWorld

Drug design, drug delivery and technologies, BioWorld
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Bio-IT World Conference & Expo Europe

Is AI on the way to designing drugs? Astrazeneca thinks so

Dec. 1, 2023
By Shani Alexander
No Comments
Artificial Intelligence (AI) driven tools have the ability to design new drugs, with a bit of help from humans, said Anders Hogner, from Astrazeneca plc’s R&D department at the Bio-IT World Conference & Expo Europe in London. “We don’t have anything out there yet,” he added, but the company appears to be working on it.
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Images showing the green fluorescence signals in different body parts of the live-birth chimeric monkey.
Drug Design, Drug Delivery & Technologies

1st chimeric monkey born with large embryonic stem cell contribution

Nov. 9, 2023
By Anette Breindl
No Comments
Investigators at the Chinese Academy of Sciences have generated a chimeric monkey by injecting an embryonic stem cell into the morula, which is an extremely early embryo consisting of 16 to 32 cells. The animal survived for only 10 days, and it is not the first live birth of a chimeric primate. But it is the first such chimera with contributions from an embryonic stem cell, and that stem cell contributed a far higher proportion of cells in the newborn than have been achieved in previous attempts at creating chimeras.
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Vial and syringe with DNA

In HIV, gene therapy could be alternative path to functional cure

Oct. 27, 2023
By Anette Breindl
No Comments
At the 30th Annual Congress of the European Society for Gene and Cell Therapy in Brussels this week, researchers presented both preclinical and clinical strategies for applying gene therapy to a functional HIV cure. At a Wednesday session on Infectious Diseases & Vaccines, Alessio Nahmad, of Tabby Therapeutics Ltd., described using B cells edited to express broadly neutralizing antibodies (bnAbs) 3BNC117 to deliver high titers of antibodies in mice.
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Photo of Loong Wang, Thong Le and Alice Chen
Drug Design, Drug Delivery & Technologies

Automera launches with $16M series A funding to tackle protein degradation

Oct. 27, 2023
By Tamra Sami
No Comments
Fledgling biotechnology company Automera has launched in Singapore with $16 million in series A funding to develop its autophagy-targeting chimera small molecules (AUTACs) platform technology. Automera co-founder and chief technology officer Loong Wang told BioWorld that he and his business partner, Taiyang Zhang, decided to move into the biotechnology space in 2021.
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AI generated illustration of lungs in the human body
Cancer

ESMO 2023: New approaches to old targets, including HER2 and p53

Oct. 23, 2023
By Mar de Miguel
No Comments
Some cancers with a poor prognosis have had no new treatments in decades. Advances in the genetic characterization of these tumors now offer a range of possibilities for the development of new therapies that could completely change the quality of life and survival of these patients.
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Nobel Prize graphic with illustrations of Moungi Bawendi, Louis Brus and Alexei Ekimov
Drug Design, Drug Delivery & Technologies

Nobel Prize in Chemistry 2023 goes to quantum dots, which illuminated the path to nanotechnology

Oct. 4, 2023
By Mar de Miguel
No Comments
Quantum dots, a phenomenon in quantum physics that alters the energy of electrons and changes the properties of particles, caught the attention of the Royal Swedish Academy of Sciences (KVA) for the 2023 Nobel Prize in Chemistry. Alexei Ekimov and Louis Brus received the award for their discovery; Moungi Bawendi, for developing its applications. With their work, “in equal shares,” said the Secretary General of KVA Hans Ellegren, the three scientists have laid the foundations of nanotechnology, a tool that we see today in our homes, on televisions and LED lamps, or in laboratories and hospitals for designing new drugs or new strategies against cancer.
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Nobel Prize graphic with illustrations of Katalin Karikó and Drew Weissman
Infection

Perseverance on mRNA therapy research wins the 2023 Nobel Prize in Medicine after saving millions of lives

Oct. 2, 2023
By Mar de Miguel
No Comments
Researchers who follow their instincts and achieve slow results while trying to break barriers have little support. They replace it with persistence. This is the story of Katalin Karikó and Drew Weissman. What was once a dream in their minds was later a success. Their work together for decades was essential to achieving mRNA vaccines, and their perseverance was rewarded today with the 2023 Nobel Prize in Medicine.
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Mosaic illustration of a mouse
Neurology/Psychiatric

Genetic editing of individual cells points to late targets for developmental disorders

Sep. 28, 2023
By Mar de Miguel
No Comments
A new gene editing method uses the CRISPR technique to modify the cells of an organ in vivo, creating a mosaic used to identify the effects of each altered gene. Scientists from the Swiss Federal Institute of Technology (ETH) in Zürich developed this technology called AAV-Perturb-seq, based on adeno-associated virus (AAV) to target, edit and analyze single-cell genetic perturbations.
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Art concept for gene therapy research
Genetic/Congenital

Machine learning tool Alphamissense analyzes human mutations to predict diseases

Sep. 19, 2023
By Mar de Miguel
No Comments
Proteome analysis with artificial intelligence has made it possible to create a catalog of all possible missense mutations in the human genome to predict diseases. The new Alphamissense tool from the technology company Google Deepmind, available online, will allow scientists to refine diagnoses and design more tailored treatment strategies for patients suffering from pathologies associated with these variants.
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Cancer research illustration
Cancer

Multiple KRAS targeting strategies paving way for combination therapies

Aug. 25, 2023
By Mar de Miguel
No Comments
KRAS-mutated tumors were once untreatable. In fact, KRAS was something of a poster child for so-called undruggability. Several laboratories are investigating strategies to address other mutations and uses beyond non-small cell lung cancer (NSCLC) and colorectal cancer. If you can't bind KRAS to block it, use a glue or combine multiple weapons. This is the idea behind two new approaches that target cancers caused by this proto-oncogene.
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