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Drug research illustration
Substance Use & Poisoning

ADX-106772 reduces oxycodone taking and seeking in rats

July 25, 2023
Researchers from Addex Therapeutics Ltd. have published preclinical data for the novel positive allosteric modulator of the metabotropic glutamate mGlu2 receptor, ADX-106772, being developed for the treatment of opioid use disorder (OUD).
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Vaccine vial and syringe
Substance Use & Poisoning

TLR7/8 agonist enhances efficacy of M-sKLH vaccine for opioid use disorder

May 24, 2023
At the recent ASPET meeting, University of Minnesota and University of Montana researchers presented data from studies to determine the ability of the Toll-like receptor 7 (TLR7) and TLR8 agonist INI-4001 to enhance the efficacy of the heroin vaccine M-sKLH for the treatment of opioid use disorder.
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Substance Use & Poisoning

New opioid receptor modulator has the noncompetitive advantage

March 29, 2023
By Anette Breindl
Researchers at Indiana University Bloomington have developed allosteric modulators of the opioid receptor that were superior to the opioid antidote naloxone at blocking the effects of fentanyl in vitro. They presented their work in a session on “Progress towards more efficacious medicine: Antibiotics and antidotes” at the 2023 spring meeting of the American Chemical Society (ACS).
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Acetaminophen pills
Substance Use & Poisoning

JNJ-26366821 repairs acetaminophen-induced liver injury in mice

March 23, 2023
Acetaminophen (APAP) is a very common nonprescription analgesic, harmless at low doses, that can cause acute liver injury and even death from acute liver failure when overdosed. The temporal course of acetaminophen overdose-induced liver injury (AILI) can be depicted in two stages – injury and recovery.
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