Atai Life Sciences NV has been awarded a multiyear, milestone-driven grant worth up to $11.4 million by the National Institute on Drug Abuse (NIDA) to support development of Atai’s novel 5-HT2A/2C receptor agonists with nonhallucinogenic potential for opioid use disorder.

Elysium Therapeutics Inc. aims to tackle the problem of opioid overdose with a longer-lasting rescue agent that gets around the not-much-publicized problem of fentanyl rebound, or re-narcotization, which happens when the standard reverser wears off and the culprit drug stays active in the body, potentially killing the patient.

Elysium Therapeutics Inc. aims to tackle the problem of opioid overdose with a longer-lasting rescue agent that gets around the not-much-publicized problem of fentanyl rebound, or re-narcotization, which happens when the standard reverser wears off and the culprit drug stays active in the body, potentially killing the patient.

Mira Pharmaceuticals Inc. has announced new animal study results with SKNY-1, highlighting its potential as an oral therapeutic to address both obesity and nicotine addiction. This follows the recent report of in vitro data on SKNY-1.

Mira Pharmaceuticals Inc. has reported new in vitro preclinical data supporting the therapeutic potential of SKNY-1, a next-generation oral drug candidate being developed by Skny Pharmaceuticals Inc.

Indivior plc has successfully advanced its GABA-B positive allosteric modulator (PAM) program for substance use disorders through IND-enabling studies with the completion of the last preclinical safety and toxicity studies.

Research of the neuroimmune mechanisms involved in stress-related fear revealed how astrocytes interact with neurons in the amygdala. The study, led by Harvard scientists, also unveiled that this interaction recruited monocytes to the meninges during chronic stress and showed how psychedelic compounds reversed monocyte accumulation in the meninges and reduced fear behavior.