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BioWorld - Wednesday, January 14, 2026
Home » Topics » Disease categories and therapies » Substance use and poisoning

Substance use and poisoning
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Illustration of cobra in front of protein structures

An antidote to cobra venom designed with AI

Jan. 22, 2025
By Mar de Miguel
Following Nobel Prize-winning chemist David Baker’s recipe for cooking an antidote to cobra venom using artificial intelligence (AI) could be faster and more effective than currently available methods. The ingredients and steps can be found in a new study published by the University of Washington scientist in collaboration with the Technical University of Denmark. They are ready for the next steps in preclinical trials.
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Illustration of cobra in front of protein structures
Substance use & poisoning

An antidote to cobra venom designed with AI

Jan. 21, 2025
By Mar de Miguel
Following Nobel Prize-winning chemist David Baker’s recipe for cooking an antidote to cobra venom using artificial intelligence (AI) could be faster and more effective than currently available methods. The ingredients and steps can be found in a new study published by the University of Washington (UW) scientist in collaboration with the Technical University of Denmark. They are ready for the next steps in preclinical trials.
Read More
Hand holding radioactive symbol
Gastrointestinal

NIH grant supports evaluation of ghrelin for radiation-induced gastrointestinal syndrome

Jan. 20, 2025
The Feinstein Institutes for Medical Research has been awarded a 5-year, $2.9 million grant from the National Institutes of Health (NIH) to investigate the potential of human ghrelin as a medical countermeasure against radiation-induced gastrointestinal syndrome.
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Various pills and powders in small plastic ziplock bags
Substance use & poisoning

New multiorgan microphysiological model offers insights into opioid overdose and recovery

Jan. 14, 2025
In a recently published article, researchers from the University of Central Florida and collaborators reported developing a novel multiorgan microphysiological system (MPS) to simulate acute opioid overdose and recovery, addressing key challenges in opioid crisis research.
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Art concept for drug addiction
Substance use & poisoning

NIDA grant supports Sparian’s SBS-226 for opiate use disorder and withdrawal

Nov. 15, 2024
Sparian Biosciences Inc. has been awarded a $19.5 million, 5-year grant to fund development of SBS-226 from IND submission through phase I development. SBS-226 is a first-in-class dual μ-opioid receptor partial agonist and δ-opioid receptor full antagonist in development for opiate use disorder and opiate withdrawal syndrome.
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Woman using eyedrops
Ocular

Grifols partners with BARDA to test ocular immunoglobulin for sulfur mustard-induced eye damage

Oct. 23, 2024
Grifols SA has entered into a partnership with the U.S. Biomedical Advanced Research and Development Authority (BARDA) to test investigational ocular surface immunoglobulin (OSIG) eye drops for their ability to treat ocular damage from sulfur mustard exposure.
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Substance use & poisoning

Southern Research Institute and UAB Research Foundation identify new pyrazolopyrimidine compounds

Oct. 9, 2024
Southern Research Institute and UAB Research Foundation have jointly described pyrazolopyrimidines acting as bromodomain-containing protein 4 (BRD4; HUNK1) and/or receptor-interacting serine/threonine-protein kinase 3 (RIPK3) and/or interleukin-6 (IL-6) inhibitors.
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People running from cliff of pills
Substance use & poisoning

NIDA grant supports Epivario’s work on epigenetic regulator for opioid use disorder

Oct. 2, 2024
Epivario Inc. has been awarded a small business innovation research (SBIR) grant of $275,000 from the National Institute on Drug Abuse (NIDA) to advance research toward the development of a novel epigenetic regulator as a treatment for opioid use disorder.
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Pink and orange test tubes
Substance use & poisoning

Addex and Indivior select compounds from GABA-B PAM collaboration

Aug. 27, 2024
Addex Therapeutics Ltd. and Indivior plc have announced the selection of clinical candidates from their γ-aminobutyric acid subtype B (GABA-B) positive allosteric modulator (PAM) research collaboration.
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Acetaminophen pills
Substance use & poisoning

Molecular insights, potential strategy for acetaminophen-induced liver injury

Aug. 2, 2024
Researchers from the Basque Center for Cooperative Research in Biosciences (CIC bioGUNE) have demonstrated that inhibiting posttranslational modification of proteins with NEDD8, a process called neddylation, was able to prevent liver damage induced by acetaminophen overdose.
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