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Home » Topics » Disease categories and therapies » Aging

Aging
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Neurology/Psychiatric

Zywie patents polydeuterated analogues of ambroxol and bromhexine

May 22, 2023
Polydeuterated analogues of ambroxol and bromhexine have been reported in a Zywie LLC patent as potentially useful for the treatment of aging, Parkinson’s and Alzheimer’s diseases, dementia with Lewy bodies and frontotemporal dementia.
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Felix Wong, co-founder and CEO, Integrated-Biosciences
Newco news

Integrated Biosciences trains neural networks to identify novel senolytic drugs

May 4, 2023
By Cormac Sheridan
Integrated Biosciences Inc., an early-stage startup that is combining synthetic biology and machine learning in the hunt for drugs that tackle cell senescence, has demonstrated its capabilities in a newly published study in Nature Aging on May 4, 2023, which employed artificial intelligence to identify three novel compounds that are highly selective for Bcl-2 and that exhibit favorable medicinal chemistry profiles.
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Drug Design, Drug Delivery & Technologies

Integrated Biosciences trains neural networks to identify novel senolytic drugs

May 4, 2023
By Cormac Sheridan
Integrated Biosciences Inc., an early-stage startup that is combining synthetic biology and machine learning in the hunt for drugs that tackle cell senescence, has demonstrated its capabilities in a newly published study in Nature Aging on May 4, 2023, which employed artificial intelligence (AI) to identify three novel compounds that are highly selective for Bcl-2 and that exhibit favorable medicinal chemistry profiles.
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3D illustration of a eukaryotic cell
Endocrine/Metabolic

Giving yeast cells aging indecision increases longevity

May 4, 2023
By Mar de Miguel
Cells of Saccharomyces cerevisiae, a yeast used as a model for human mitosis, age in two ways. Both genomic instability and the decline of mitochondria cause cells to degenerate and die. The choice of one type or another depends on a network of genes that can be adjusted by bioengineering.
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3D rendering of alcohol dehydrogenase
Endocrine/Metabolic

Alcohol-metabolizing enzyme plays role in longevity

March 2, 2023
By Mar de Miguel
Scientists at the University of Virginia have discovered an anti-aging mechanism mediated by an enzyme that metabolizes alcohol. Alcohol dehydrogenase, which in Caenorhabditis elegans and yeast replaces the rejuvenating effect of autophagy, would reduce age-associated glycerol levels, also promoting longevity in mice and humans.
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Immune

Thymmune Therapeutics raises funding to advance thymic cell therapies

March 2, 2023
Thymmune Therapeutics Inc. has secured US$7 million in seed financing to support its work in developing scalable thymic cell therapies to restore immune function in aging and disease.
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Older person holding cane
Newco news

Cambrian’s Isterian sees aging in fibrosis as more than skin deep

Feb. 14, 2023
By Anette Breindl
Compared to the issues that come with, say, a failing liver, skin aging can look like more of a vanity problem. But aging in both tissues, and multiple others, is driven by the same underlying molecular mechanisms. One of those mechanisms is fibrosis, the cross-linking of extracellular matrix (ECM) proteins that leads to tissue stiffening. Anti-aging company Cambrian Biopharma Inc. has argued that stiffening of the ECM should be considered one of the formal hallmarks of aging.
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Cancer

Conversation between telomeres and mitochondria about aging prevents cancer

Feb. 13, 2023
By Mar de Miguel
Researchers from The Salk Institute have described a signaling pathway that sets off an unusual, autophagy-dependent cell death mechanism as a fail-safe for cells that have evaded senescence mechanisms. The scientists found a tumor suppression mechanism mediated by telomere signaling, which activated an innate immune response through mitochondrial and telomere complexes to eliminate cells with shortened telomeres.
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Robotic and human hands touching computer screen

Trudiagnostic partners with Rejuve.AI to improve chronological age prediction

Feb. 3, 2023
By Meg Bryant
Epigenetic testing company Trudiagnostic LLC has linked up with Rejuve.AI, an artificial intelligence (AI)-powered longevity research network, to develop more accurate tools for predicting chronological age. Specifically, the collaboration seeks to shed new light on the biology of aging and connectedness of DNA methylation (DNAm), metabolomics and proteomics.
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Hourglass, sunset, silhouettes
Genetic/congenital

Rockfish lifespan diversity gives insights into human aging GWAS

Jan. 16, 2023
By Anette Breindl
“Short-lived organisms represent a fundamentally different evolutionary strategy, and the idiosyncrasies influencing their aging may not apply to longer-lived models, including humans,” researchers from Harvard Medical School wrote in the Jan. 11, 2023, issue of Science Advances.


In their paper, the authors reported insights into the genomics of longevity that took advantage of an unusual animal model: rockfish.
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