Using in vivo imaging technology, investigators at the University of Utah and the University of Padua have identified a new signaling mechanism for glutamate that was linked to the onset of spreading depression or spreading depolarization, a neuronal activity pattern that plays a role in multiple neurological disease states. In mouse models of migraine, glutamate, which is the major excitatory neurotransmitter of the brain, was released in what the authors called "plumes" or puffs.
Keeping you up to date on recent developments in diagnostics, including: Speeding triage of COVID-19 patients; New tests distinguishes COVID-19 and flu; Predicting heart failure; Expanding cryptosporidiosis testing in developing regions.
Keeping you up to date on recent developments in orthopedics, including: HSS bone study sheds light on complications after spinal surgery; Simplify Medical reports first implant of its cervical artificial disc in the U.S. following FDA 1-Level approval; Scientists say xenon improves properties of maxillofacial and orthopedic implants.
Keeping you up to date on recent developments in oncology, including: Study clarifies distinct genomic features of early-onset appendiceal cancer; MET no better than EMT for cancer metastases; MRI may offer risk-stratification for glioblastoma; Study supports short telomeres as protective against cancer.
Keeping you up to date on recent developments in cardiology, including: Genes influencing CAD identified; Education reassures patients with noncardiac chest pain; Skin helps predict heart disease.
Keeping you up to date on recent developments in neurology, including: Genetic differences important in Alzheimer’s diagnosis; Stanford develops tool for studying neural activity; Gut microbiota plays a role in brain function, mood regulation.
LONDON – A study of genetic variants in patients with life-threatening COVID-19 has shed light on the mechanisms that underpin severe disease, uncovered new drug targets and pointed to approved drugs, including JAK inhibitors and phosphodiesterase type 4 inhibitors, as therapies that could aid recovery.
Keeping you up to date on recent developments in diagnostics, including: Predicting breast cancer recurrence, Comparing SARS-CoV-2 PCR tests, Paying attention to the little guy in proteomics, Increasing biomarker reproducibility
Keeping you up to date on recent developments in orthopedics, including: Can we make bones heal faster?; Risk of serious complications during knee replacement 73% higher when a tourniquet is used; Exercise may protect bone health after weight loss surgery.
Keeping you up to date on recent developments in oncology, including: New theranostic nanoparticle design combines DNA wireframe and Sgc8c aptamer; Bolting TLR agonist to antibody converts cold tumors; Rule-based screening for degraders; How stress disrupts tumor cell sleep; Combo treatment shows efficacy in treatment of ALL.
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