The microbiome has broad and deep effects on pretty much all aspects of health. So broad and so deep, in fact, that how to best translate those effects into medical interventions remains an open question.
As shown most spectacularly by the fireworks-like rise and explosion of Theranos, there is an urgent need for diagnostics that can detect very low amounts of their targets in very small sample volumes. Amplification systems exist for nucleic acids, but not for proteins. Now, researchers from the Massachusetts Institute of Technology have developed a method, which they have termed hierarchical nanofluidic molecular enrichment system (HOLMES) – named, one hopes, for Sherlock, not Elizabeth – for amplification of very low concentrations of solutes from fluids, including blood serum and urine.
Scientists from University Hospital Freiburg and the NIH have created mice that combine "microbiota and pathogens at all body sites and the tractable genetics of C57BL/6 mice."
Sexual dimorphism in gene expression is widespread across chromosomes, and is partially conserved across species from mice to humans, the first study to investigate such differences both across species and across tissues has found.
MEXICO CITY – A hepatitis B virus (HBV) cure was considered “a pipe dream for many years,” Anna Kramvis, of the University of Witwatersrand, told the audience at the 2019 HIV & HBV Cure Forum, co-organized by the International AIDS Society (IAS) Towards an HIV Cure initiative and the International Coalition to Eliminate Hepatitis B (ICE-HBV). Kramvis is also on the board of ICE-HBV
Researchers at the Weizmann Institute and the German Cancer Research Center have identified a role for the gut microbiome in modulating amyotrophic lateral sclerosis (ALS).
MEXICO CITY – Merck Sharp & Dohme's MK-8591, a nucleoside reverse transcriptase translocation inhibitor (NRTTI), impressed in both treatment and prevention studies at the 2019 International AIDS Society (IAS) Conference on HIV Science.
MEXICO CITY – The 2019 International AIDS Society (IAS) Conference on HIV Science kicked off over the weekend with the usual pre-conference workshops, including a workshop by the IAS Towards an HIV Cure initiative.
MEXICO CITY – Ten years after the RV144 "Thai trial" was the first to show that an effective HIV vaccine was possible, three efficacy trials for HIV vaccines are once again underway.
