Like everything that's been tried against Alzheimer's disease (AD) to date, a vaccination approach has resulted in failure. In fact, that failure was worse than most.

Researchers from Baylor College of Medicine have identified a metabolic target in prostate cancer, opening up the possibility for a target that could serve as an alternative or second-line treatment for hormone-targeting treatments.

Want to figure out how to manipulate a cell? See how other cells do it. That, in a nutshell, is the premise underlying the biomedical use of exosomes, small packets of – well, of lots of different things.

Want to figure out how to manipulate a cell? See how other cells do it.

Researchers at the University of Chicago have identified a new member of the tripartite motif (TRIM) family of proteins that could control the reactivation of several herpesviruses, including the cancer-associated Kaposi's sarcoma herpesvirus (KSHV). 

Researchers at the University of Iowa have identified a protein fragment of the structural protein junctophilin-2 that could partially prevent pathological processes contributing to heart failure.

Researchers at the Dana-Farber Cancer Institute and the Swiss Friedrich Miescher Institute have developed a method to find compounds that will induce the degradation of zinc fingers, which collectively are thought to comprise the single largest group of transcription factors in the human proteome.

The good news is that BACE-1 inhibitors hit their targets.

Researchers from MD Anderson Cancer Center have published new findings that argue for a role of the long noncoding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) as a metastasis suppressor, rather than promoter, as previous work had suggested. 

The good news is that BACE-1 inhibitors hit their targets. In that sense, in fact, the class has been "incredibly successful," Bruce Albala, executive director of neuroscience clinical development in Eisai Inc.'s neurology business group, told the audience at a symposium titled "Is BACE1 a suitable drug target for prevention and treatment of Alzheimer's disease?" at the 2018 Clinical Trials in Alzheimer's Disease (CTAD) meeting.