Researchers from the University of Toronto's Sunnybrook Health Sciences Centre have demonstrated that they could safely and reversibly open the blood-brain barrier (BBB) by using MRI-guided ultrasound combined with microbubbles.
Researchers from the Japanese Kobe and Kyoto Universities have demonstrated that in mice, innate immune activation via Toll-like receptors (TLRs) was necessary for social defeat stress to translate into depressive behaviors.
Scientists from the Georgia Institute of Technology have developed polymeric microparticles that could be loaded with therapeutic bacteriophages, and delivered to the lungs via inhalation. Treatment with the phages protected both regular mice and mouse models of cystic fibrosis from otherwise lethal infections with Pseudomonas aeruginosa.
Using genome editing in liver cells, researchers from the University of Pennsylvania have lowered the levels of LDL "bad" cholesterol in monkeys by up to 60 percent.
Researchers at University College London have demonstrated that prenatal gene therapy for the lysosomal storage disorder Gaucher disease was more effective than gene therapy immediately after birth.
To date, increases in healthspan have not kept up with those in lifespan, and many elderly, despite surviving cancer and cardiovascular disease that would have once killed them, are in poor health overall. Recent studies have suggested that senescent cells, which are not dying but have stopped dividing, are contributors to the frailty that accompanies aging. Now a team from the Mayo Clinic has put that idea to the test directly, transplanting senescent cells into young mice.
