Researchers at the University of Maryland, Baltimore County, have developed a suitcase-sized device that is poised to disprove the old adage that of fast, cheap and good, you can pick any two.

In the course of screening for synthetic lethal interactions, researchers have identified a new mechanism for the formation of DNA lesions that trap the enzyme poly(ADP-ribose) polymerase (PARP) as well as dozens of previously unknown genetic changes that could sensitize cells to PARP inhibition.

Researchers at the Japanese National Cancer Center Research Institute have identified an "epigenetic reconditioning" approach that could force liver cancer cells to differentiate, rendering them less aggressive. Epigenetic changes are a frequent feature of liver tumors, which have few therapeutic options.

Scientists at the Johns Hopkins Medical School have demonstrated that the experimental glucagon-like peptide 1 (GLP-1) receptor agonist NLY-01 (Neuraly Inc.) was protective against Parkinson's disease (PD) in two separate mouse models.

Innate immune system activation appears to be linked to late-onset Alzheimer's disease (AD), which has led to speculation that infections might play a role in AD risk. Now, a team from the Mount Sinai School of Medicine has shown that individuals with AD had high levels of two separate herpes viruses in their brain. 

Researchers from the RV411 study group have reported that even when HIV-infected individuals started antiretroviral treatment (ART) within two weeks of infection, it could not prevent the establishment of a viral reservoir nor the occurrence of viral rebound if treatment was interrupted. 

Researchers at the University of Washington have used information from acquired mutations in mismatch repair genes to assess whether the same mutations, when they occurred in the germline, put those that harbored them at risk of Lynch syndrome.