Researchers from Gilead Sciences Inc., with colleagues from academia, have identified the mechanism by which a major protein of the hepatitis B virus (HBV) promotes transcription of viral DNA – a finding that could lead to new drug targets.
Researchers have developed a so-called human challenge model for dengue vaccine, and used it to test a vaccine that was shown to evoke an immune response to all four strains of dengue virus, and protect against subsequent infection with serotype 2, which has been the most challenging serotype from a vaccine development standpoint.
Narrow-spectrum antibiotics are one possible weapon in the fight against drug resistance. But like so many scientifically promising ideas, there are hazards to the idea in the messier situations that predominate in the clinic.
Staphylococcus aureus is the S in ESKAPE, an acronym for the six bacteria that are considered the greatest threats to public health by the Infectious Disease Society of America. Like the rest of the ESKAPE pathogens, resistance to the first-line drugs that were once effective against them is widespread. In S. aureus, that resistance is to beta-lactams, a group of drugs that includes penicillin and methicillin.
A genomic study has identified individuals with a mutation that led to both high levels of high-density lipoprotein (HDL) and an increased risk of heart disease. The findings further call into question the idea that HDL is good for cardiovascular health.
Scientists have discovered that triple-negative breast cancer (TNBC) that are driven by overexpression of the oncogene Myc have changes to their metabolism that can be targeted with inhibitors of fatty acid oxidation.
By comparing the genomic landscape of multiple metastases from the same patient to each other, and to the primary tumor, scientists have shown that prostate cancer metastases within the same patient were similar to each other in terms of their mutations and gene expression profiles.
More than 100 years since the oncogene SRC first came to the attention of the biomedical research community, researchers have for the first time identified individuals with a germline SRC mutation.
Researchers have shown that keeping mice with Leigh syndrome, one of the more frequent mitochondrial diseases, in a low-oxygen environment reduced their disease symptoms and could more than double their life span.
