Senti Biosciences Inc. stands to receive more than $645 million in up-front, opt-in and milestone payments through a new collaboration and option agreement with Spark Therapeutics Inc.
Cachexia, Teresa Zimmers told the audience at the Annual Meeting of the American Association for Cancer Research (AACR), is "woefully understudied for the outsized impact it has on cancer patients." The condition, which is currently defined as weight loss and muscle wasting, is the direct cause of death in an estimated 25% to 30% of cancer patients. But it is the main subject of only 0.1% of research papers and 0.2% of clinical trials.
Keeping you up to date on recent developments in oncology, including: Popcorn-like gold nanofilms for detection of miRNA in cancer; Myeloid cells differ in primary and recurrent glioblastoma; Premetastatic niche is prepared via leaky gut in colorectal cancer; Brain metastases of breast cancer depend on fatty acid synthesis.
Researchers at the J. Craig Venter Institute and the National Institute of Standards and Technologies have identified seven genes that are indispensable in order for the "minimal genome" or JCV3.0 cell to divide into two equal daughter cells.
Keeping you up to date on recent developments in neurology, including: DBS shows promise in treating OCD patients with comorbidities; COVID-19-associated seizures linked to higher risk of death; Antibodies could make things worse in neurodegeneration; Ultrarare variants give insights into schizophrenia.
Keeping you up to date on recent developments in diagnostics, including: Blood-based test may help detect early Alzheimer’s disease; AI-based tool helps predict course of COVID-19; Myeloid cells differ in primary and recurrent glioblastoma.
BioWorld looks at translational medicine, including: Premetastatic niche is prepared via leaky gut in colorectal cancer; Brain metastases of breast cancer depend on fatty acid synthesis.
Researchers at Kumamoto University have identified mutations in the proteoglycan Tsukushi as a cause of hydrocephalus. The study, which was published in the March 31, 2021, issue of Science Translational Medicine, adds to the evidence that a significant proportion of hydrocephalus are due to genetic alterations.
The animal world is full of species that can perform astonishing, and sometimes disgusting, feats. Take vultures, for example. “They eat this rotten meat that is full of pathogens and toxins, and they stay healthy,” Neta Raab told BioWorld. Raab is the co-founder and CEO of Wild Biotech Ltd., an Israeli startup that is seeking to understand gut microbiome contributions to these animal superpowers, and harness them for therapeutic use.
