Friday’s report that the Merck and Co. Inc./Newlink Genetics Corp. VSV-EBOV vaccine was effective at preventing infections also shone a spotlight on the method used to test the vaccine, namely, ring vaccination.
In one sense, the genetics of Huntington's disease are no mystery at all. The genetic cause – a DNA triplet expansion in the huntingtin gene – is clear. And it is also clear that those who have the mutation will inevitably get the disease.
Researchers from the Korean Seoul National University and Yonsei University School of Medicine have used the CRISPR/Cas9 editing system to correct a hemophilia gene in induced pluripotent stem cells (iPSCs) and showed that such cells enabled mice with an otherwise lethal form of hemophilia A to survive.
Two studies reported new links between the gut and the brain, describing new interrelationships among early life stress, depression and the microbiome.
Multiple myeloma has joined the ranks of tumor types that show benefit from immunotherapy treatment, with early stage clinical results reported in the July 20, 2015, issue of Nature Medicine.
By following up a serendipitous discovery with detailed sequencing, scientists have been able to gain new insights into both a rare genetic disease, and a common immune system protein.
Researchers at the University of Minnesota have gained new insights into the relationship between enterovirus infection, heart function, and the protein dystrophin, better known for its role in Duchenne's muscular dystrophy.
As master switches for a number of processes that are important to cell growth, and, with mTOR and Akt, part of the network that integrates nutritional status information with growth decisions, PI3 kinase inhibitors have "enormous promise attached to them" as cancer treatments, Dario Altieri told BioWorld Today.
Of the many types of evidence that a protein might make a good drug target, human genetic studies linking its gene to the disease being targeted is considered one of the better ones.
