Two recent studies have independently identified macropinocytosis, a nutrient procurement pathway whereby cancer cells take up extracellular fluid droplets containing proteins and other macromolecules, as a promising new therapeutic target for pancreatic ductal adenocarcinoma (PDAC).
Pre-existing insulin-secreting pancreatic beta cells, but not their progenitors, have been shown to contribute to new beta cells in the adult pancreas, according to a Chinese study led by scientists at the Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences.
An international whole genome sequencing study has shown that diphtheria, an easily preventable but highly contagious potentially fatal upper respiratory tract infection by Corynebacterium diphtheriae, is evolving antimicrobial resistance, which could lead to the loss of protection that has evolved with changes in the diphtheria toxin.
Taiwanese researchers have elucidated the signaling mechanism downstream of IL-17 receptor B and shown that its blockade using a neutralizing antibody reduced pancreatic cancer tumorigenesis and metastasis, while prolonging the life of tumor-bearing mice.
A study led by scientists at Osaka University Graduate School of Medicine has identified the previously unknown molecular mechanism underlying bone marrow regeneration after chemotherapy, which damages hematopoietic stem and progenitor cells.
A study of the epigenetic enzyme Pr-set7/Set8 by researchers at Duke-NUS Medical School in Singapore has shown it to play a key role in stimulating neural stem cells (NSCs) from their quiescent state, enabling their proliferation and the generation of new neurons.
The molecular mechanisms underlying control of antibiotic production by hormones in soil bacteria have been elicited for the first time in a study by scientists at University of Warwick in Coventry, U.K., and at Monash University in Melbourne, Australia.
A study by researchers at Nanjing University has demonstrated that in mice, depression-like phenotypes induced by paternal stress can be inherited by the offspring through a causal role of microRNAs in the father's sperm.
A study led by scientists at the Korean Research Institute of BioScience and Biotechnology in Daejeon is the first to demonstrate that Dilp8/INSL3-Lgr3/8-NUCB, neuropeptide y signaling may be a potential therapeutic target in cancer anorexia and cachexia, which is associated with increased cancer mortality.
