Pancreatic cancer is a highly lethal digestive malignancy with a 5-year survival rate of 10%. So far, the available therapeutic strategies are scarce and the few advancements made, as is the case of poly(ADP-ribose) polymerase (PARP) inhibitors, are only effective in 5% to 7% of patients. Investigators at the Third People’s Hospital of Chengdu and collaborators described the synergistic effect obtained by the combined administration of LB-23, a PARP1 degrader, and JQ1, a BRD4 inhibitor, in homologous recombination (HR)-proficient pancreatic cancer models.
Scenic Immunology BV has disclosed glutaminyl-peptide cyclotransferase (QPCT; QC) and/or glutaminyl-peptide cyclotransferase-like protein (QPCTL; isoQC) inhibitors reported to be useful for the treatment of cancer.
Anocca AB has submitted its first clinical trial application (CTA) to the EMA for a phase I/II multi-asset umbrella trial, VIDAR-1. The application covers ANOC-001 as the initial product in the VIDAR-1 program targeting mutated KRAS in advanced pancreatic cancer.
Transposon Therapeutics Inc. has acquired a portfolio of novel nucleoside analogues from Primefour Therapeutics Inc. for the targeted treatment of pancreatic cancer, certain other solid tumors and hematologic cancers.
Targeted protein degradation has gained attention in recent years due to its potential to hit proteins that are difficult to engage with conventional small molecules. Pin1 is an enzyme associated with tumor formation overexpressed in pancreatic cancer cells or cancer-associated fibroblasts in particular.
Wigen Biomedicine Technology (Shanghai) Co. Ltd. has synthesized compounds acting as membrane-associated tyrosine- and threonine-specific Cdc2-inhibitory kinase (PKMYT1) inhibitors reported to be useful for the treatment of cancer.
At the European Association of Nuclear Medicine meeting, Monopar Therapeutics Inc. presented the preclinical characterization of MNPR-101, a first-in-class urokinase-type plasminogen activator receptor (uPAR)-targeting radiopharmaceutical agent with high stability in vivo and more than 1 week of shelf-life in its labeled form, [177Lu]-MNPR-101.
