Since abnormal choline accumulation in cancer cells has been strongly correlated with malignant tumor growth, researchers from Tokyo Medical University aimed to analyze the functional expression of choline transporters in human hepatocellular carcinoma (HCC).
A lot of focus has been put on targeting T-cell immunoreceptor with Ig and ITIM domains (TIGIT) for HIV infection treatment, but no attention has been given to targeting its ligand, CD155.
Researchers from Georgetown University presented data from a study that aimed to assess the intrinsic mechanisms by which myeloid cells regulate their activation states during remyelination and to identify new therapeutic targets for multiple sclerosis (MS).
THADA (thyroid adenoma associated) is a target gene of chromosomal aberration in thyroid adenomas, which has been previously identified as a type 2 diabetes mellitus (T2DM)-associated gene. Recently, researchers from Shandong University and affiliated organizations investigated the effects of THADA deficiency on glucose homeostasis.
Squamous cell carcinoma (SCC) consists of heterogeneous tumors that originate from surface epithelial cells, with a dynamic keratinocyte (KC)-specific network of epigenetic modifications and transcription factors (TFs) being involved in squamous cell fate determination and oncogenesis. In recently published work, researchers from Massachusetts General Hospital and affiliated organizations aimed to identify kinases that control these processes and could therefore have therapeutic applications.
