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BioWorld - Friday, December 12, 2025
Home » targets

Articles Tagged with ''targets''

Blood cells and bacteria
Infection

pCTS-L as new therapeutic target in potentially lethal sepsis

Feb. 15, 2023
Cathepsin L (CTS-L) is a lysosomal enzyme responsible for degrading endocytosed proteins to generate immunogenic antigens for adaptive immunities. In the current study, researchers reported data from a study that aimed to assess the potential of targeting procathepsin L (pCTS-L) as a potential therapeutic strategy against sepsis.
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Dividing breast cancer cell.
Cancer

SULF1 knockdown seen to modulate TNBC metastatic potential

Feb. 15, 2023
Triple-negative breast cancer (TNBC) still remains as one of the most aggressive breast cancer types among women, with high metastatic potential and ability to shift towards epithelial-mesenchymal transition (EMT).
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Neonatal/Pediatrics

Targeting PFKFB3 as a potential strategy in infantile hemangioma treatment

Feb. 14, 2023
Infantile hemangioma (IH) is the most common benign vascular tumor seen in childhood. After an early proliferative phase in the first weeks of life, the majority of hemangiomas complete their growth and start to involute by approximately 12 months.
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Brain illustration
Cancer

Anoctamins identified as new therapeutic targets in diffuse midline glioma

Feb. 14, 2023
Anoctamins are a class of calcium-activated chloride ion channels, which have been recently implicated in cancer pathogenesis. Researchers from Telethon Kids Institute and the University of Western Australia aimed to characterize the expression of the anoctamin family in diffuse midline glioma (DMG).
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Hematologic

TFPI potentially useful as target for treatment of undiagnosed bleeding disorders, researchers unveil

Feb. 14, 2023
Undiagnosed bleeding disorders put people at risk due to bleeding without an optimal treatment strategy. Spanish researchers from the Hospital Universitario La Paz and Universidad Autónoma de Madrid have focused on the targeting of tissue factor pathway inhibitor (TFPI) as a potential approach for this medical need by using TFPI blocker antibodies.
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Cross-section of brain
Neurology/Psychiatric

circSCMH1 promotes vascular repair after stroke through FTO-regulated methylation

Feb. 10, 2023
Circular RNAs (circRNAs) are non-coding RNAs abundant in the brain, and several of them are functionally involved in ischemic stroke.
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Obesity, fat cell research concept image
Endocrine/Metabolic

ADAMTS14 behind obesity, researchers find

Feb. 9, 2023
Obesity is an important cause of death worldwide, and it is defined as a body mass index >30 kg/m2. Genome-wide association studies have been successful at identifying genomic loci tied to obesity.
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Illustration of motor neuron connecting to muscle fiber
Neurology/Psychiatric

Targeting coregulators of polyQ-expanded androgen receptor attenuates the SBMA phenotype in animal models

Feb. 9, 2023
Spinal-bulbar muscular atrophy (SBMA), also called Kennedy disease, is an X-linked genetic disorder in which the loss of motor neurons affects the parts of the nervous system that control voluntary muscle movement.
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A microscopic image of liver tissue affected by metabolic dysfunction-associated steatotic liver disease.
Gastrointestinal

VEGF-B antagonism as a therapeutic strategy against NAFLD

Feb. 8, 2023
Insulin resistance in type 2 diabetes (T2DM) is associated with hepatosteatosis and the development of nonalcoholic fatty liver disease (NAFLD), with the pathogenesis of NAFLD being complex and involving the crosstalk between the liver and white adipose tissue (WAT).
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3D illustration of a osteoclast
Musculoskeletal

Targeting La protein might be approach for osteoclast-driven fibrous dysplasia

Feb. 8, 2023
Bone-resorbing osteoclasts are key players in bone remodeling and their dysfunction has been implicated in several bone disorders such as fibrous dysplasia. Osteoclasts derive from monocytes stimulated by several cytokines, such as M-CSF and RANKL.
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