Distant metastasis and drug resistance are the main causes of colorectal cancer (CRC)-derived mortality. Identifying the underlying mechanisms driving metastasis is key for improving its therapy. Epithelial-to-mesenchymal transition (EMT) promotes the migration and invasion of tumor cells, allowing them to metastasize distant organs. Chinese researchers put the focus on dishevelled segment polarity protein 3 (DVL3) due to its involvement in the Wnt signaling pathway.
Symmetric dimethylarginine (SDMA) is one of the byproducts of protein methylation, and it has been previously identified as an independent cardiovascular risk factor in patients with chronic kidney disease. The majority of SDMA is excreted through renal tubules; however, its effect on kidney in pathological conditions is not fully understood. In a recent study, researchers from Shuguang Hospital aimed to investigate the role of SDMA in renal tubulointerstitial fibrosis.
Transcription factor SP1 is a member of the Kruppel-like factor that has been shown to be overexpressed in several cancer types, including cervical cancer, and is associated with poor prognosis when overexpressed; assessing the impact of SP1 on tumor progression in cervical cancer was the aim of a recently published study by Wenzhou Medical University investigators.
Researchers from Sun Yat-Sen Memorial Hospital and affiliated organizations published data from a study that aimed to explore the mechanism of prostate cancer (PCa) metastasis to discover an intrinsic biomarker for metastatic PCa (mPCa).
Sensitized nociceptors, such as during inflammation, respond to non-noxious stimuli. The precise molecular mechanisms for sensitization to mechanical stimuli are not well defined. Recent findings have suggested piezo-type mechanosensitive ion channel component 2 (Piezo2) to be part of these mechanisms.
Although FMS-like tyrosine kinase 3 (FLT3) inhibitors have shown success treating FLT3-mutated acute myeloid leukemia (AML), around 30% to 50% of patients show primary resistance to both type I and type II inhibitors. Therefore, identifying therapeutic strategies to overcome this resistance and enhance the efficacy of FLT3 inhibitors remains an urgent need.
Previous studies have shown that ovarian cancer (OC) has strong tumor heterogeneity, resulting in high recurrence and metastasis rates. In recently published work, researchers from Capital Medical University (CMU) applied single-cell transcriptomics to identify metastasis-associated cell clusters and key genes involved in OC metastasis.
Recent findings in murine studies have unveiled a circuit linking the basolateral amygdala to the anterior cingulate cortex (BLA-ACC circuit) as a key for chronic pain-induced depression symptoms; researchers aimed to clarify the mechanisms behind this phenotype. Stimulation of this circuit led to the upregulation of semaphorin 4A (SEMA4A), which was the focus of the study.
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