Researchers from Georgetown University presented data from a study that aimed to assess the intrinsic mechanisms by which myeloid cells regulate their activation states during remyelination and to identify new therapeutic targets for multiple sclerosis (MS).
THADA (thyroid adenoma associated) is a target gene of chromosomal aberration in thyroid adenomas, which has been previously identified as a type 2 diabetes mellitus (T2DM)-associated gene. Recently, researchers from Shandong University and affiliated organizations investigated the effects of THADA deficiency on glucose homeostasis.
Squamous cell carcinoma (SCC) consists of heterogeneous tumors that originate from surface epithelial cells, with a dynamic keratinocyte (KC)-specific network of epigenetic modifications and transcription factors (TFs) being involved in squamous cell fate determination and oncogenesis. In recently published work, researchers from Massachusetts General Hospital and affiliated organizations aimed to identify kinases that control these processes and could therefore have therapeutic applications.
Previous research has suggested that neurons in multiple sclerosis (MS) exhibit metabolic exhaustion, believed to be caused by chronic hyperexcitability, which can lead to neurodegeneration. Researchers from Heidelberg University and affiliated organizations aimed to investigate the role of nodal Kv7 (outward rectifying) and perinodal oligodendroglial Kir4.1 (inward rectifying) channels as potential therapeutic targets for neuroprotection through balancing of neuronal excitability caused by inflammatory demyelination.
A ‘guilt by association’ study linking disease-associated proteins to proteins for which there was no evidence of any role in pathology, has identified groups of proteins interacting with genes that genome-wide association studies (GWAS) have previously implicated in 21 disease areas. Revealing these interactions has thrown up new drug targets.
