Scientists at USA Elixiria Biotech Inc. and colleagues described data from preclinical studies evaluating the potential of the peroxisome proliferator-activated receptor γ (PPARγ) agonist, ELB-00824, for protection against chemotherapy-induced neuropathic pain (CINP).
While NASA gets the glory for exploration of the vast unknown of space, Bionaut Labs Ltd. hopes to reap similar fame by transforming travel through the brain with Bionauts, microrobots designed to deliver therapeutic payloads across the blood-brain barrier. To help achieve that mission, the company raised $43.2 million in a series B financing round led by Khosla Ventures.
Epidermal growth factor receptor (EGFR) is a target in many cancers, but EGFR inhibitors have displayed little utility in treating glioblastoma (GBM) due to limited blood-brain barrier (BBB) penetration.
Researchers at Stanford University have developed a method to efficiently replace microglia, which are brain-specific immune cells, via a modified bone marrow transplant.
Researchers at Stanford University have developed a method to efficiently replace microglia, which are brain-specific immune cells, via a modified bone marrow transplant.
An international study led by scientists at the Free University of Brussels in Belgium has shown that Wnt ligand signaling specificity is adjustable and may represent a means of treating CNS disorders by normalizing blood-brain barrier (BBB) function.
A number of possible mechanisms have been explored, but there is still no safe, reliable and universally applicable method for delivering drugs across the blood-brain barrier (BBB) to treat central nervous system diseases. Now researchers have succeeded in tuning the effect of methamphetamine, a cause of BBB breakdown, enabling brain penetration of small molecules and therapeutic proteins, without damaging the epithelial cells that constitute the main physical element of the barrier.
Researchers at Curtin University in Perth, Australia, have discovered that leakage from blood into the brain of fat-carrying particles transporting toxic proteins are a possible cause of Alzheimer's disease.
A Japanese study has discovered a new means of regulating endogenous gene expression in the CNS, using systemically administered antisense oligonucleotides (ASOs) in rodents, which facilitates development of ASO-based therapies for patients with neurological diseases requiring prolonged treatment.
