The BCL6 degrader BI-3802 works by inducing polymerization of its target protein, which in turn triggers the addition of ubiquitin tags on the polymerized structure and degradation by the proteasome, scientists reported in the Nov. 18, 2020, issue of Nature.
Keeping you up to date on recent developments in oncology, including: Nanoparticles may blunt TRIM37’s impact on metastasis in triple-negative breast cancer; Glycolysis inhibition via collateral lethality; Making exceptional responders unexceptional; Protons may spare cancer patients a hit to the heart.
Keeping you up to date on recent developments in cardiology, including: 3D-printed heart models aim to train future surgeons; Researchers: Digital program lowered patients’ cholesterol, blood pressure; Additional monitoring may be needed for those at risk of atrial fibrillation.
By screening the microbiomes of marine organisms, scientists at the University of Wisconsin have identified nearly 150 potential new antifungal compounds, they reported in the November 20, 2020, issue of Science.
Keeping you up to date on recent developments in neurology, including: Wireless chip developed to improve brain research; Diabetes increases damage around amyloid plaques in Alzheimer’s; Smartphone keystrokes show promise in monitoring progression of MS.
Keeping you up to date on recent developments in diagnostics, including: Imaging methods reveal underlying cause of unexplained heart attack; Questionnaire predicts people at high risk for heart disease; Bias skews tally on imaging diagnostic test accuracy studies.
A study by Australian microbiologists at Queensland, Melbourne and Griffiths universities has shown that the candidate neurodegenerative disease drug PBT-2, combined with a polymyxin antibiotic, induced potent antimicrobial activity against polymyxin-resistant gram-negative pathogens.
Keeping you up to date on recent developments in orthopedics, including: Exoskeleton-assisted walking improves mobility in individuals with spinal cord injury; Skoltech scientists developed a novel bone implant manufacturing method; Novel technique 'stuns' arthritis pain in shoulder and hip; New research reveals potential treatment to delay and manage osteoarthritis.
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