The mosaic loss of Y chromosome in myeloid cells is a major risk factor for increased incidence of cardiovascular and fibrotic diseases during aging. The authors of a study published in the July 14, 2022, online edition of Science found that bone marrow-derived myeloid cells exhibited mLOY during aging.

Using long-term in vivo imaging combined with computational modeling, a multinational team of researchers has gained new insights into what makes potential stem cells able to fulfill their role functionally.

An effective treatment could be found for one of the most aggressive pediatric cancers, alveolar rhabdomyosarcoma (aRMS).

Researchers have discovered how the tau protein turns from a normal to a disease state in Alzheimer's disease (AD) and have shown how the discovery could potentially deliver a therapeutic target.

Several genetic studies in a range of model organisms have pointed to an important role for the B-cell lymphoma 2 (BCL2)-associated athanogene 3 (BAG3) gene in the maintenance of cardiac function.

Research carried out by a team at St. Jude Children's Research Hospital in Memphis highlights the importance of carefully assessing the mouse model you plan to use before starting preclinical medical research.

No matter how they come about, functional impairments in the DNA repair protein BRCA1 will hamper cells' ability to repair their genome, and increase the chances that a cell will become cancerous. However, researchers from the Jackson Laboratory for Genomic Medicine reported in the July 6, 2022, issue of Science Translational Medicine that reduced BRCA1 activity that was due to methylation of its promoter differed from BRCA1 mutation in terms of its response to platinum chemotherapy.

SARS-CoV-2 infection caused damage to brain blood vessels via a cascade of immune system reactions that was most likely initiated by antibody-dependent cytotoxicity, researchers from the National Institute of Neurological Disorders and Stroke reported in the July 5, 2022, online issue of Brain.

Researchers have identified an RNA-binding protein that played a role in colon cancer relapse, offering new insights into how cells persist in the presence of chemotherapy.

The University of Central Florida (UCF) and Orlando Health are testing new medical technology designed to identify blood clots more quickly in surgery. The monitoring device consists of a small optical fiber that uses red blood cells to track the process of blood coagulation in patients so doctors can watch for life threatening blood clot formation.