Severe malaria infections caused by malaria could disrupt hematopoietic processes in mouse models, resulting in faster turnover of hematopoietic stem cells (HSCs) and drastically affecting their function, researchers from Imperial College London and The Francis Crick Institute reported in the November 23, 2020, online issue of Nature Cell Biology.
Bluestar Genomics Inc. and the University of Chicago revealed the publication of a genome-wide 5-hydroxymethylcytosine (5hmC) map across multiple human tissue types. In the report, published Dec. 2, 2020, in Nature Communications, the researchers detailed the development of the map by characterizing the genomic distributions of 5hmC in 19 human tissues derived from 10 organ systems.
Keeping you up to date on recent developments in orthopedics, including: Researchers develop new biomaterial that helps bones heal faster; Obesity increases the risk of early hip fracture in postmenopausal women; Vitamin D regulates calcium in intestine differently than previously thought.
Combining metabolic intervention with T-cell immunotherapy is safe and resulted in improved efficacy in two mouse models of solid tumors, providing an alternative combination strategy for boosting solid tumor immunotherapy, according to a new study by scientists at China Pharmaceutical University.
Keeping you up to date on recent developments in oncology, including: New assay may aid in the use of proteases as diagnostic for a range of cancers; New vulnerability in ‘KL’ KRAS subtype; Ferropoptosis gains new credibility as cancer treatment.
An international study led by Nanyang Technological University in Singapore has designed and synthesized broad-spectrum antimicrobial polymers (AMPs) and demonstrated the safety and efficacy of two such agents against multidrug-resistant (MDR) bacteria in mouse models of sepsis.
Despite concerns to the contrary, none of the mutations currently documented in the SARS-CoV-2 virus appear to increase its transmissibility in humans, according to a new analysis of viral genomes from 46,723 people in 99 countries who contracted COVID-19.
BioWorld looks at translational medicine, including: Overfeeding slows down liver’s response to glucose changes; Oncolytic virus combines best of both immune worlds.
Keeping you up to date on recent developments in cardiology, including: Remote help to lower BP, control cholesterol; Improving screening for dual heart disease; Candidate shows promise in reducing heart failure.
LONDON – The Google artificial intelligence company Deepmind has developed an algorithm that can predict the 3D structure of a protein from its amino acid sequence, making it possible to solve the structures of proteins, such as G-protein coupled receptors (GPCRs), which are a mainstay of drug targeting but whose structure is challenging to determine with current methods.
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