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BioWorld - Sunday, July 3, 2022
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Penn researchers develop neoantigen quality algorithm to guide immunotherapy

Oct. 21, 2019
By Stacy Lawrence
No Comments
Researchers at the Abramson Cancer Center at the University of Pennsylvania have developed an algorithm to better personalize immunotherapy treatment. The algorithm works by examining neoantigen quality, not just their quantity. Neoantigens are proteins that are the result of genetic mutations in a tumor.
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BioWorld MedTech's Neurology Extra

Oct. 21, 2019
By Andrea Applegate and Anette Breindl
No Comments
Keeping you up to date on recent developments in neurology.
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Penn researchers develop neoantigen quality algorithm to guide immunotherapy

Oct. 21, 2019
By Stacy Lawrence
No Comments
Researchers at the Abramson Cancer Center at the University of Pennsylvania have developed an algorithm to better personalize immunotherapy treatment. The algorithm works by examining neoantigen quality, not just their quantity. Neoantigens are proteins that are the result of genetic mutations in a tumor.
Read More

BioWorld MedTech's Diagnostics Extra

Oct. 18, 2019
By Meg Bryant
No Comments
Keeping you up to date on recent developments in diagnostics.
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New small-molecule inhibitors block apoptosis in mice

Oct. 16, 2019
By John Fox
No Comments
Australian researchers have developed the first potent new small-molecule inhibitors capable of blocking the activation of apoptotic cell death before it causes damage to mitochondria, they reported in a study published in the Oct. 7, 2019, issue of Nature Chemical Biology.
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Australia's Orthocell ready to file interim results for Celgro

Oct. 15, 2019
By Tamra Sami
No Comments
PERTH, Australia – Following stunning interim clinical results for its Celgro nerve regeneration treatment in quadriplegic patients, regenerative medicine company Orthocell Ltd. will focus all its efforts on gaining quick U.S. FDA approval based on the early results.
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Calling bias sinks CCR5 work but is 'likely unique' to variant

Oct. 15, 2019
By Nuala Moran
No Comments
LONDON – A paper that raised concerns for the future health of Lulu and Nana, the world's first gene-edited babies, has been fully retracted at the request of the authors, after they failed to identify a problem in data from the U.K. Biobank on which their analysis was based. The study published in Nature Medicine in June, concluded the edits the twin girls are purported to have in their CCR5 chemokine receptor gene is associated with a 21% increase in mortality in middle and old age.
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Harvard researchers test in vivo, fluorescent, synthetic biology microbiome tool

Oct. 14, 2019
By Stacy Lawrence
No Comments
Synthetic biology is seeing rapid advances, but the medical applications have thus far remained largely elusive. But now researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School (HMS) have developed a tool that can track specific populations of bacteria in the gut of living organisms and document population changes over time.
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New small-molecule inhibitors block apoptosis in mice

Oct. 14, 2019
By John Fox
No Comments
Australian researchers have developed the first potent new small-molecule inhibitors capable of blocking the activation of apoptotic cell death before it causes damage to mitochondria, they reported in a study published in the Oct. 7, 2019, issue of Nature Chemical Biology. Those first-in-class inhibitors will be useful tools for evaluating the mechanisms underlying apoptosis, assessing the impact of the pharmacological blockade of apoptosis in experimental models and potentially have multiple clinical indications.
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Bench Press: BioWorld looks at translational medicine

Oct. 14, 2019
By Anette Breindl
No Comments
Researchers from Columbia University have demonstrated that correcting mutations in the schizophrenia risk gene SetD1 in adult mice reversed cognitive impairments, suggesting that, like a number of other brain disorders, schizophrenia's malfunctions begin in early development, but remain in place via ongoing active processes rather than reaching a point of no return. 
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