"RNA was long thought to be an 'undruggable' target for small molecules, because most cellular RNAs have extensive secondary structure, but only limited tertiary structure," Matthew Disney told BioWorld Science.

Single-cell genomic analysis has shown that mutations in the KRAS oncogene co-opt a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells, initiating pancreatic ductal adenocarcinoma, Chinese researchers reported in the November 3, 2020, edition of Nature Cancer.

BioWorld looks at translational medicine, including: CDK 4/6 inhibitors affect transcriptional landscape.

Japanese researchers have developed a new organoid biobank with which to identify molecular subtypes of rare gastroentero-pancreatic neuroendocrine neoplasms using genotype-phenotype mapping, they reported in the November 6, 2020, online edition of Cell.

The use of liquid biopsies, tests that look for variants in cell-free DNA (cfDNA) shed by tumors into blood plasma, could lead to misdiagnosis and inappropriate treatment in many cancers, according to University of Washington researchers. The tests misidentified a noncancer mutation that is particularly common in older people as a mutation used as a biomarker for PARP inhibitors indicated for use in prostate cancer, a study published in JAMA Oncology found, but the problem likely extends to other malignancies.

BioWorld looks at translational medicine, including: Autophagy linked to neurotransmission.