Mirati Therapeutics Inc.’s update on the phase I/II Krystal trial of the KRAS-G12C-targeting adagrasib (MRTX-849) was arguably the most eagerly awaited news, and certainly the most eagerly awaited KRAS-targeting news, to come out of the 2020 EORTC-NCI-AACR (ENA) Molecular Targets meeting. KRAS is one of the most frequently mutated oncogenes across a wide swath of solid tumors, and has been one of the toughest nuts to crack as far as druggability is concerned.
A new tool for mobile devices can diagnose stroke as accurately as an emergency medicine specialist in just minutes, enabling patients to get brain-saving therapies in time for maximum benefit. According to researchers from Pennsylvania State University and Houston Methodist Hospital, the artificial intelligence (AI)-based tool could counterbalance physician biases, reducing both overuse of CT scans and underdiagnosis of mild and moderate stroke.
Researchers at Ontario’s University of Waterloo have developed a palm-sized device that uses radio waves to read blood glucose levels, as well as artificial intelligence (AI) software to get near instantaneous results.
Keeping you up to date on recent developments in neurology, including: MIT develops wearable sensor for ALS patients; Cord blood DNA can hold clues for early ASD diagnosis and intervention; ENIGMA consortium offers hope for improving treatment of brain injuries.
French researchers have shown that modifying peripheral macrophages could quell microglial activation in the central nervous system, slowing the rate of decline and extending survival in mouse models of amyotrophic lateral sclerosis.
Keeping you up to date on recent developments in diagnostics, including: Study underscores long-term impact of COVID-19; CT scan enhancement via deep learning; Caution in screening for large fetus size.
A multi-institutional team of researchers has implicated lipid droplets, which are key energy storage units of individual cells, in innate immune defense. "Until now it was thought that [lipid droplets] were at the service of viruses or bacteria during infection," Albert Pol told BioWorld. The new study, which was published in the Oct. 16, 2020, issue of Science, demonstrated that cells also use the droplets to coordinate their defense.
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