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BioWorld - Wednesday, August 10, 2022
Home » Topics » Science

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Small and selective

Small molecules clear mutant Huntingtin protein

Oct. 31, 2019
By John Fox
No Comments
A Chinese study has identified small-molecule compounds that can selectively reduce levels of the mutant Huntingtin (HTT) protein involved in the pathogenesis of Huntington's disease (HD), and possibly other neurodegenerative diseases involving mutant protein accumulation.
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BioWorld MedTech's Orthopedics Extra

Oct. 31, 2019
By Holland Johnson
No Comments
Keeping you up to date on recent developments in orthopedics.
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KRAS protein
AACR-NCI-EORTC 2019

At Molecular Targets Meeting, a bonanza of ways to thwart once-undruggable KRAS

Oct. 30, 2019
By Anette Breindl
No Comments
BOSTON, Mass. – KRAS used to be the poster child for undruggability. No more. Amgen Inc. and Mirati Therapeutics Inc. are in the clinic with KRAS inhibitors. Boehringer Ingelheim GmbH is planning to join them by the end of the year. And multiple other companies are moving programs forward.
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BioWorld MedTech's Oncology Extra

Oct. 30, 2019
By Mark McCarty and Anette Breindl
No Comments
Keeping you up to date on recent developments in oncology.
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BioWorld MedTech's Cardiology Extra

Oct. 29, 2019
By Liz Hollis
No Comments
Keeping you up to date on recent developments in cardiology.
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Bench Press for Oct. 28, 2019

Oct. 28, 2019
No Comments
BioWorld looks at translational medicine.
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Tea time for diabetics

Green tea-triggered genetic control system reported

Oct. 28, 2019
By John Fox
No Comments
Chinese researchers have developed the first green tea-triggered genetic control system for future gene- and cell-based precision medicine applications, and then used it to treat diabetes in mice and monkeys, they reported in the Oct. 23, 2019, issue of Science Translational Medicine.
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BioWorld MedTech's Neurology Extra

Oct. 28, 2019
By Andrea Applegate
No Comments
Keeping you up to date on recent developments in neurology.
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Less is more

Rightsizing brain activity increases lifespan, but REST is not all good

Oct. 28, 2019
By Anette Breindl
No Comments
Two very different roles were reported for the protein REST last week. In adults, REST activation appeared to extend lifespan by reducing overall brain activity. Principal investigator Bruce Yankner, professor of genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging, told BioWorld MedTech that in postmortem brain samples of individuals who had had no cognitive impairments at the time of their death, his team found "a correlation between down-regulation of excitation and extended longevity."
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Neurons
Less is more

Rightsizing brain activity increases lifespan, but REST is not all good

Oct. 25, 2019
By Anette Breindl
No Comments
Two very different roles were reported for the protein REST last week. In adults, REST activation appeared to extend lifespan by reducing overall brain activity. Principal investigator Bruce Yankner, professor of genetics at Harvard Medical School and co-director of the Paul F. Glenn Center for the Biology of Aging, told BioWorld that in postmortem brain samples of individuals who had had no cognitive impairments at the time of their death, his team found "a correlation between down-regulation of excitation and extended longevity."
Read More
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