Keeping you up to date on recent developments in orthopedics, including: Rapid recovery protocol can lead to increased range of motion after TKA; Study compares racial disparities in unilateral vs. bilateral knee replacement surgery; Botox for TMJ disorders may not lead to bone loss in the short term.
BioWorld looks at translational medicine, including: Reversal of pumping direction is reversal of fortune for tumor cells; Cholesterol drug affects checkpoint blockade via MHC1; Heart development protein has role in adult immunity.
"RNA was long thought to be an 'undruggable' target for small molecules, because most cellular RNAs have extensive secondary structure, but only limited tertiary structure," Matthew Disney told BioWorld Science.
Keeping you up to date on recent developments in oncology, including: Blood test does well in distinguishing between malignant, benign growths; PARP inhibition can assist tumor cells; CDK 4/6 inhibitors affect transcriptional landscape.
Single-cell genomic analysis has shown that mutations in the KRAS oncogene co-opt a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells, initiating pancreatic ductal adenocarcinoma, Chinese researchers reported in the November 3, 2020, edition of Nature Cancer.
Keeping you up to date on recent developments in cardiology, including: What is causing COVID-19 blood clots?; Using machine learning to predict survival rates with OHCA; Remote cardiac rehabilitation proves itself.
Japanese researchers have developed a new organoid biobank with which to identify molecular subtypes of rare gastroentero-pancreatic neuroendocrine neoplasms using genotype-phenotype mapping, they reported in the November 6, 2020, online edition of Cell.
The use of liquid biopsies, tests that look for variants in cell-free DNA (cfDNA) shed by tumors into blood plasma, could lead to misdiagnosis and inappropriate treatment in many cancers, according to University of Washington researchers. The tests misidentified a noncancer mutation that is particularly common in older people as a mutation used as a biomarker for PARP inhibitors indicated for use in prostate cancer, a study published in JAMA Oncology found, but the problem likely extends to other malignancies.
Keeping you up to date on recent developments in neurology, including: AI helps detect brain aneurysms on CT angiography; BBB studies advancing focused ultrasound treatment for Parkinson’s; Study reveals unexpected protective role for brain swelling after injury.
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