Researchers at City of Hope have used a combination of oncolytic virus and CD19-targeting CAR T cells to first force expression of CD19 on tumor cells and then hunt down those cells, eradicating tumors in immunocompetent mouse models and endowing them with immunity to later re-administration of tumor cells.
Keeping you up to date on recent developments in diagnostics, including: A simple point-of-care COVID-19 test; A deep-learning method to predict AMD risk; AP-1 and antidepressant action; Orasure collection device included in Miradx EUA.
An Australian study led by University of Melbourne scientists has identified a previously unknown role for the hepatokine, sparc-related modular calcium-binding protein 1 (SMOC1), in suppressing hepatic glucose production. The investigators reported their results in the Sept. 2, 2020, edition of Science Translational Medicine.
Keeping you up to date on recent developments in orthopedics, including: Implant choice more important than surgeon skill for hip replacement success; Vertebral body tethering shows clinical success as treatment for scoliosis; Hip fracture risk linked to nanoscale bone inflexibility; Bioventus reports first use of its Signfuse bioactive bone graft in strip format.
Keeping you up to date on recent developments in oncology, including: Denoising algorithm may boost signal-to-noise ratios in prostate MRI; Cross-reactive immunity helps antitumor response; iBET you I can kill those metastases; Transatlantic assault on cancer announced.
Keeping you up to date on recent developments in cardiology, including: 3D printing of heart valve models; Findings challenge recommendations for antiplatelet treatment after TAVI; Telehealth could help those with high BP avoid heart attack, stroke.
With COVID-19, questions about how infections cause lasting immunity, or don’t, and how you know and what it all means for vaccines have become a matter of public focus. But some immunologists have been pondering those questions for years. “The immune system has a very good memory,” Bali Pulendran told BioWorld. “Clearly, some viruses and some pathogens can enter the body and stimulate the immune system, and the immune system can remember that encounter for decades.”
Keeping you up to date on recent developments in neurology, including: Blood-based test used to predict who is likely to develop psychotic disorders; Study could lead to more personalized choices for OCD treatment; Nerve cells differ before birth in people with ASD.
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