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Home » Topics » Science

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Structure of the engineered pre-F

Bench Press for May 1, 2020

May 1, 2020
By Anette Breindl
BioWorld looks at translational medicine, including: Neutralizing RSV; Insulin cuts both ways in vasculature; Transcriptomic insights into Parkinson’s disease; Restoring synaptic transmission for rare neurodevelopmental disease; Polymerase k and drug resistance; Sphingolipids accumulate in neurodegeneration; How does innate immunity remember? Not via polycomb; Antibiotics affect oxycodone effects; Cabo as next annual shot?
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BioWorld MedTech’s Neurology Extra for May 1, 2020

May 1, 2020
By Andrea Applegate
Keeping you up to date on recent developments in neurology, including: Light-based stimulation relieves symptoms of Parkinson's, Implant-free optogenetics minimizes brain damage during neuronal stimulation, Persistent and worsening insomnia may predict persistent depression in older adults.
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AACR 2020

Phosphatases are yin to kinases’ yang

May 1, 2020
By Anette Breindl
The activity of many proteins is controlled through phosphorylation by kinases and dephosphorylation by phosphatases. Overactive kinases are one of the major drivers of tumors and, as a result, kinase inhibitors are a mainstay of oncology drug development. But “activation of the brakes, the phosphatases, could be equally therapeutically viable for the treatment of a broad range of cancers” to kinase inhibition, Goutham Narla told the audience at the 2020 American Association for Cancer Research (AACR) meeting.
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BioWorld MedTech’s Diagnostics Extra for April 30, 2020

April 30, 2020
By Meg Bryant and Anette Breindl
Keeping you up to date on recent developments in diagnostics, including: Deep neural network for colorectal polyp classification; Biomarkers signal chemo-induced heart damage; AI helps gauge risk of severe COVID-19 infection; Platelets play role in Tylenol toxicity.
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Vero E6 cell infected with SARS-CoV-2
Thwarting the hijacker

In vitro study gives ‘blueprint’, drug leads for SARS-CoV-2

April 30, 2020
By Anette Breindl
A multi-institutional group led by the University of California at San Francisco’s Quantitative Biosciences Institute (QBI) has identified more than 200 host proteins that interacted with SARS-CoV-2 viral proteins during infection, creating “a blueprint of how SARS-CoV-2 hijacks human cells,” QBI Director Nevan Krogan told reporters. They then used that blueprint to identify 10 drugs, some FDA approved and some in clinical trials, that were able to inhibit viral growth in cell culture assays, marking them for further study as potential antivirals. The work also identified one compound, dextromethorphan, that appeared to facilitate viral growth.
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BioWorld MedTech’s Orthopedics Extra for April 29, 2020

April 29, 2020
By Holland Johnson
Keeping you up to date on recent developments in orthopedics, including: Physio support in COVID-19 recovery; Co-delivery of IL-10 and NT-3 to enhance spinal cord injury repair; European countries face a costly 23% increase in fragility fractures by 2030.
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Coronavirus and DNA

Cooperative research effort taking aim at genetics affecting COVID-19 infection

April 28, 2020
By Nuala Moran
LONDON – Leading genome sequencing groups are launching the first meta-analysis in the hunt for genetic factors that explain why some people have worse COVID-19 symptoms than others, after agreeing to share patient sequence data from around the world.
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BioWorld MedTech’s Oncology Extra for April 28, 2020

April 28, 2020
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology, including: Small tumors and large motion effects dampen treatment effect in IMPT; Pancreatic cancer uses autophagy to hide from immune system; NRF2 wakes sleeping tumor cells; Cancer renders patients more susceptible to COVID-19.
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BioWorld MedTech’s Cardiology Extra for April 27, 2020

April 27, 2020
By Liz Hollis
Keeping you up to date on recent developments in cardiology, including: Helping heart cells regenerate; Heart failure hormone has role in sepsis; Speeding up ER treatment; Cheating cell death improves infarct outcomes.
Read More

BioWorld MedTech’s Neurology Extra for April 24, 2020

April 24, 2020
By Andrea Applegate and Anette Breindl
Keeping you up to date on recent developments in neurology, including: Nanocarrier developed for drug delivery across the BBB; 3D face analysis could screen for sleep apnea; Long noncoding RNA has sex-specific role in depression; Noncoding TET2 variants affect neurodegeneration risk.
Read More
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