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Silhouette made of crumpled paper illustrating depression

Proline links gut microbiome to depression

May 9, 2022
By Nuala Moran
If it is now acknowledged the gut microbiota plays a role in the pathophysiology of depression, the specific biochemical mechanisms underlying this connection are hard to unpick and poorly understood.
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Breast cancer illustration
ESMO Breast Cancer 2022

Taking aim at tumor metabolism, while taming toxicity

May 6, 2022
By Anette Breindl
There are 40 years of history behind the development of phosphoinositide 3-kinase (PI3K) inhibitors, Rebecca Dent told her audience at ESMO Breast Cancer 2022. And there have been success stories. There are five FDA-approved PI3K inhibitors in several cancer types, and in April, the FDA approved Vijoice (alpelisib; Novartis AG) for PIK3CA-related overgrowth spectrum, a rare disorder resulting from germline mutations of PIK3CA.
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Neurology illustration

Researchers discover HDAC1 as the cause of immune abnormalities in autistic mouse models

May 5, 2022
By Tamra Sami
Researchers from the RIKEN Brain Science Institute in Japan have shown in mouse models that idiopathic autism could be caused by epigenetic abnormalities in hematopoietic cells during fetal development which resulted in immune dysregulation in the brain and gut.
Read More
Lymph nodes

In times of need, fat cells take on immune functions

May 4, 2022
By Anette Breindl
Fat cells surrounding the lymph nodes could switch jobs in response to a distant infection, taking on immune cell functions, researchers at Johns Hopkins University reported in the May 3, 2022, online issue of Cell Metabolism.
Read More
3D illustration of heart cross section

Tripartite interactions between nervous system, immune cells and plaques drive atherosclerosis

May 3, 2022
By Subhasree Nag
In a study reported in the April 27, 2022, online edition of Nature, an international team of researchers has for the first time demonstrated a three-way interaction between neurons, immune cells and plaques as a key component of atherosclerosis.
Read More
Cancer cell and DNA

To escape radiation, tumor cells reversibly damage their DNA

May 2, 2022
By Nuala Moran
Researchers have uncovered a new pathway via which cancer cells evade the effects of radiation by deploying self-inflicted – but reversible – DNA breaks to stop the cell cycle and ensure their survival. The lesions are caused by caspase-activated DNase (CAD), an enzyme involved in DNA fragmentation during cell death. In response to radiation, tumor cells activate CAD, causing genome-wide DNA breaks at sites involved in DNA repair.
Read More
Inflammation illustration

Innate immune memory underlies inflammatory comorbidities: study

May 2, 2022
By Anette Breindl
Researchers at the University of Pennsylvania have gained new insight into how different inflammatory conditions reinforce each other via trained innate immunity.
Read More
Cancer cell and DNA

To escape radiation, tumor cells reversibly damage their DNA

April 29, 2022
By Nuala Moran
Researchers have uncovered a new pathway via which cancer cells evade the effects of radiation by deploying self-inflicted – but reversible – DNA breaks to stop the cell cycle and ensure their survival.
Read More
Multiple sclerosis

Study finds targets of T-cell response in multiple sclerosis

April 28, 2022
By Anette Breindl
Screening a panel of potential autoantigens, investigators at the Karolinska Institute have identified four autoantigens that are targeted by the T cells of multiple sclerosis patients.
Read More
Antibiotic resistant bacteria inside a biofilm

ECCMID 2022: In antibiotic development, scientific ingenuity meets a dysfunctional marketplace

April 26, 2022
By Anette Breindl
Antibiotics drugs discovery, Ursula Theuretzbacher told the audience at the 2022 European Congress of Clinical Microbiology & Infectious Diseases (ECCMID), has more than one challenge to overcome.
Read More
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