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RNA strand

PILA identified as lncRNA that enhances NF-kappaB signaling and osteoarthritis

May 26, 2022
By Nuala Moran
New research points a finger at a previously unknown long noncoding RNA (lncRNA) as playing a critical role in activating nuclear factor kappa B (NF-kappaB) inflammatory responses and driving the progression of osteoarthritis of the knee.
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Lysine reactive salicylaldehyde probe exhibits kinase selectivity with sustained occupancy

May 25, 2022
By Subhasree Nag
Jack Taunton and colleagues from the University of California, San Francisco have developed salicylaldehyde-based chemical probes that reversibly and covalently modify the catalytic lysine of protein kinases, with sustained occupancy in cells and animals.
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Mammogram

Loss of PHGDH potentiates metastatic dissemination

May 24, 2022
By Nuala Moran
Variable expression of an enzyme in the initial tumor has been identified as an early step in the process of migration and growth of cells to form remote metastases in breast cancer.
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Cancer diagnostic illustration

Deep Visual Proteomics links protein abundance to cellular phenotypes and preserves spatial context

May 23, 2022
By Nuala Moran
A German-Danish team of researchers has developed a new imaging technology that is able to quantify the number of expressed proteins in a given cell, map tissue and cell-type specific proteomes, and identify drug targets.
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Cancer research illustration

New phospholipid anticancer target identified

May 20, 2022
By John Fox
A multicenter Japanese study led by researchers at Tokyo University of Science has confirmed that the epithelial phospholipid, phosphatidylinositol bisphosphate, could partially halt cancer progression, making it an attractive new target molecule for novel anticancer treatments.
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Youth COVID test

New findings help to identify those most at risk for developing severe COVID-19 complications

May 19, 2022
By Tamra Sami
Findings from three recent studies are shedding light on the pathways that are activated in severe cases of COVID-19, paving the way for earlier diagnosis and more targeted treatments.
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Patient-derived antibody activates innate immune system

May 18, 2022
By Anette Breindl
A target-agnostic search has yielded a patient-derived antibody that activated the innate immune system, researchers from Atreca and Stanford University reported in the May 4,2022, issue of the Proceedings of the National Academy of Sciences.
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Aging illustration

Multiple aging hallmarks show up as epigenetic changes

May 16, 2022
By Anette Breindl
Age is the biggest risk factor for just about every common disease in high-income countries, which suggests that slowing down cellular aging would have massive effects on individual and public health. Delaying the average onset of Alzheimer’s disease by five years, for example, would roughly halve its prevalence. But in practice, there are no approved anti-aging medications.
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Cancer cell and DNA

Diabetic foot ulcers hold clues to tumor suppression

May 16, 2022
By W. Todd Penberthy
New genomic research has increased the understanding of surprising links between diabetic foot ulcers and carcinomas.
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Assembling a draft Human Cell Atlas

Across body parts, ‘parts list’ gives insights into the lives of a cell

May 12, 2022
By Anette Breindl
“People often think about the genome as the blueprint of the organism, but that’s not really correct,” Steven Quake told reporters at a Science press briefing earlier this week. “The genome is more of a parts list, because every cell type uses different parts.” Quake is president of the Chan Zuckerberg Biohub Network, and professor of bioengineering and applied physics at Stanford University.
Read More
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