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Assembling a draft Human Cell Atlas

Across body parts, ‘parts list’ gives insights into the lives of a cell

May 12, 2022
By Anette Breindl
“People often think about the genome as the blueprint of the organism, but that’s not really correct,” Steven Quake told reporters at a Science press briefing earlier this week. “The genome is more of a parts list, because every cell type uses different parts.” Quake is president of the Chan Zuckerberg Biohub Network, and professor of bioengineering and applied physics at Stanford University.
Read More
Back pain

Inflammation is key to preventing chronic pain, study finds

May 11, 2022
By Anette Breindl
More than 10% of Americans suffer from chronic pain, and how to prevent acute pain from turning chronic has been a critical question in pain research. But according to a study published in the May 11, 2022, issue of Science Translational Medicine, that approach has it backwards. In several animal models of pain, the resolution of acute pain was an active process. Chronic pain happened when those active processes failed to occur.
Read More
Glucose testing

Type 2 diabetes getting precision medicine makeover

May 11, 2022
By Nuala Moran
Type 2 diabetes is known to involve many different underlying mechanisms, but the considerable heterogeneity in the phenotype is mostly ignored in how it is treated. Now, researchers at University of Dundee, U.K., have developed a method for visualizing this heterogeneity and shown how the risks of complications, such as chronic kidney disease or peripheral neuropathy, differ by phenotypes.
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Breast cancer illustration
ESMO Breast Cancer 2022

Taking aim at tumor metabolism, while taming toxicity

May 10, 2022
By Anette Breindl
There are 40 years of history behind the development of phosphoinositide 3-kinase (PI3K) inhibitors, Rebecca Dent told her audience at ESMO Breast Cancer 2022. And there have been success stories. There are five FDA-approved PI3K inhibitors in several cancer types, and in April, the FDA approved Vijoice (alpelisib; Novartis AG) for PIK3CA-related overgrowth spectrum, a rare disorder resulting from germline mutations of PIK3CA.
Read More
Fallopian tubes, ovaries and uterus

Comparative study focuses lens of human reproductive aging

May 10, 2022
By Anette Breindl
A comparison of seven nonhuman primate species has found both similarities and differences among the effects of age on female reproduction.
Read More
Silhouette made of crumpled paper illustrating depression

Proline links gut microbiome to depression

May 9, 2022
By Nuala Moran
If it is now acknowledged the gut microbiota plays a role in the pathophysiology of depression, the specific biochemical mechanisms underlying this connection are hard to unpick and poorly understood.
Read More
Breast cancer illustration
ESMO Breast Cancer 2022

Taking aim at tumor metabolism, while taming toxicity

May 6, 2022
By Anette Breindl
There are 40 years of history behind the development of phosphoinositide 3-kinase (PI3K) inhibitors, Rebecca Dent told her audience at ESMO Breast Cancer 2022. And there have been success stories. There are five FDA-approved PI3K inhibitors in several cancer types, and in April, the FDA approved Vijoice (alpelisib; Novartis AG) for PIK3CA-related overgrowth spectrum, a rare disorder resulting from germline mutations of PIK3CA.
Read More
Neurology illustration

Researchers discover HDAC1 as the cause of immune abnormalities in autistic mouse models

May 5, 2022
By Tamra Sami
Researchers from the RIKEN Brain Science Institute in Japan have shown in mouse models that idiopathic autism could be caused by epigenetic abnormalities in hematopoietic cells during fetal development which resulted in immune dysregulation in the brain and gut.
Read More
Lymph nodes

In times of need, fat cells take on immune functions

May 4, 2022
By Anette Breindl
Fat cells surrounding the lymph nodes could switch jobs in response to a distant infection, taking on immune cell functions, researchers at Johns Hopkins University reported in the May 3, 2022, online issue of Cell Metabolism.
Read More
3D illustration of heart cross section

Tripartite interactions between nervous system, immune cells and plaques drive atherosclerosis

May 3, 2022
By Subhasree Nag
In a study reported in the April 27, 2022, online edition of Nature, an international team of researchers has for the first time demonstrated a three-way interaction between neurons, immune cells and plaques as a key component of atherosclerosis.
Read More
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