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Cancer cells under magnifying glass

Gain-of-function study identifies T-cell boosters

March 29, 2022
By Anette Breindl
In the attempts to improve CAR T-cell function, Neville Sanjana told BioWorld Science, "most of the focus is on making the CAR better."
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Neural network

Phosphatidylserine is crucial for synaptic pruning in adult-born neurons

March 28, 2022
By Subhasree Nag
A multidisciplinary team of scientists has discovered the mechanism that controls synaptic pruning of new neurons in the adult brain. The team discovered that microglial cells control the number of synapses by "eating" excessive synapses.
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Pregnancy test

Nonhormonal male contraceptive prevents pregnancy in partners

March 25, 2022
By Anette Breindl
Researchers at the University of Minnesota have identified a nonhormonal form of contraception for males, which left male mice temporarily sterile after a few weeks of administration.
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Pancreatic tumor metastasis In a mouse

‘Trojan horse’ approach redirects tetanus immune response to tumors

March 23, 2022
By Anette Breindl
Researchers at the Albert Einstein College of Medicine have turned pancreatic cancer’s immunosuppressive properties, and mechanisms, against itself. The team have used the bacterium Listeria monocytogenes as a delivery vehicle for tetanus toxoid protein, a highly immunogenic antigen that is used in childhood tetanus vaccinations. In mouse models of pancreatic cancer, treatment reduced both primary tumors and metastases, and extended survival.
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Ovarian cancer illustration

Researchers discover genetic targets linking endometriosis, ovarian cancer subtypes

March 22, 2022
By Tamra Sami
Researchers at the University of Queensland have found a genetic link between endometriosis and ovarian cancer subtypes, enabling them to identify potential drug targets for therapy and increasing the understanding of both diseases.
Read More
Antibodies

Immune suppressive glycoprotein-targeting MAb reported

March 21, 2022
By David Ho
A team of researchers at the National Cheng-Kung University in Taiwan has created monoclonal antibodies (MAbs) that can neutralize the secretory glycoprotein chitinase-3-like-1 (CHI3L1) to stop cancer growth.
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Brain and blood cells

Blood stem cells treat brain disease after transplant

March 18, 2022
By Anette Breindl
Researchers at Stanford University have developed a method to efficiently replace microglia, which are brain-specific immune cells, via a modified bone marrow transplant.
Read More
Gloved hand holding petri dish in lab

Food-borne bacterium's neuroinvasion mechanism discovered

March 18, 2022
By Nuala Moran
A new mechanism has been discovered by which cells infected with the foodborne pathogen Listeria monocytogenes are able to escape the immune response, and which at the same time confers a higher probability that infected cells will adhere to and infect cerebral vessels and cross the blood-brain barrier.
Read More
Inserting contact lens into eye

New smart contact lens may diagnose, treat diabetes more comfortably

March 17, 2022
By Gina Lee
A smart contacts lens that detects diabetes and treats diabetic retinopathy could provide patients with a more comfortable alternative to insulin shots and monitoring blood glucose levels. The product was developed by a research team at the Pohang University of Science & Technology (POSTECH) that includes Sei Kwang Hahn, the CEO of Seoul, South Korea-based Phi Biomed Co. Ltd.
Read More
Brain and blood cells

Blood stem cells treat brain disease after transplant

March 17, 2022
By Anette Breindl
Researchers at Stanford University have developed a method to efficiently replace microglia, which are brain-specific immune cells, via a modified bone marrow transplant.
Read More
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