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Stomach and esophagus

Infection in thymus causes autoimmunity in stomach

March 3, 2022
By Anette Breindl
In the February 28, 2022, issue of the Journal of Experimental Medicine, researchers from Washington University in St. Louis have demonstrated that in a mouse model, there is a causal link between murine roseolovirus and autoimmune gastritis.
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Viruses-infecting-neurons.png

Neuropathy may unify disparate long COVID symptoms

March 2, 2022
By Anette Breindl
Researchers from Massachusetts General Hospital have identified peripheral neuropathy in more than half of a group of long COVID patients, suggesting that it may be a mechanism that contributes to multiple, seemingly disparate, long COVID symptoms.
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Neurons

Study finds potential entry points to Huntington's therapy

March 1, 2022
By John Fox
A Chinese study led by researchers at Fudan University in Shanghai has described a novel strategy to target the "undruggable" mutant Huntingtin protein by screening for compounds that directly bind to the 'undruggable' target and rescue disease-relevant phenotypes.
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Skeletal system

Study identifies potential new bone disease target

Feb. 28, 2022
By John Fox
Scientists at Osaka University have discovered that intercellular communication via extracellular vesicles from osteoblasts, cells that are specialized for laying down new bone, is a key factor for the transition from bone formation to resorption via a microRNA (miRNA)-mediated mechanism.
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Coronavirus and DNA

Risk SNP for COVID-19 signals protection against HIV

Feb. 25, 2022
By Anette Breindl
A study from the Max Planck Institute for Evolutionary Anthropology and the Karolinska Institute has shown that individuals who carry the major genetic risk variant for severe COVID-19 infection are less likely to contract HIV.
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Lung illustration

Lung microbiome affects brain immune cells

Feb. 25, 2022
By Anette Breindl
Antibiotic treatment that changed the lung microbiome affected the activity of microglia, the brain-specific version of macrophages, and could prevent the development of the multiple sclerosis model experimental autoimmune encephalitis in mice.
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Cardiovascular.png

Novel target identified for long QT

Feb. 23, 2022
By Subhasree Nag
Timothy syndrome, a rare autosomal-dominant disorder, is characterized by presence of a heart arrhythmia (long QT syndrome), which causes the cardiac muscle to take longer than usual to recharge between beats and can result in sudden death. Now scientists at Columbia University have discovered that a common FDA-approved over-the counter cough suppressant, dextromethorphan, can shorten the prolonged QT intervals in both cellular and mouse models of TS.
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Microscopic visualization of a cancerous cell

EBV antibodies put to good use through retargeting

Feb. 22, 2022
By Anette Breindl
Researchers at Inserm have developed a method to direct pre-existing antibodies toward new targets. Their bimodular fusion proteins could be a broadly useful method for expanding access to antibody therapy. In a study that appeared in the Feb. 11, 2022, issue of Science Advances, the teams showed that antibodies to Epstein-Barr virus (EBV), which are present in 95% of the global population, could be redirected to a target cell of their choosing by fusing an EBV antigen to a cellular targeting ligand.
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Neurology illustration

Engineered Wnt ligands repair BBB in neuro disorders

Feb. 22, 2022
By John Fox
An international study led by scientists at the Free University of Brussels in Belgium has shown that Wnt ligand signaling specificity is adjustable and may represent a means of treating CNS disorders by normalizing blood-brain barrier (BBB) function.
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Rendering of splint on trachea

Georgia Tech 3D-printed splint to sub for missing windpipe in newborns

Feb. 18, 2022
By David Godkin
Engineers at Atlanta-based Georgia Tech’s Center for 3D Medical Fabrication have developed a 3D-printed tracheal splint as an airway for children born with a rare condition known as tracheal agenesis or the absence of a trachea or windpipe.
Read More
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