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Kidneys

Osmolytes induce kidney EMT

March 11, 2022
By Subhasree Nag
A team of researchers at Tokyo Metropolitan University have discovered that osmolytes such as mannitol, which are used to treat increased intraocular or intracranial pressure, can cause kidney damage by inducing hyperosmotic stress that leads to epithelial-mesenchymal transition (EMT) of the tubular epithelial cells.
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Petri dishes

Study casts new light on autoimmune disease etiology

March 10, 2022
By John Fox
Major histocompatibility complex (MHC) class II molecules aberrantly induced by viral infection or inflammation, have been shown for the first time to form self-antigen/MHC class II complexes that initiate autoantibody production, according to a Japanese study published in the March 4, 2022, edition of Science Advances.
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Illustration of COVID-19 virus cells affecting brain

Matching scans show COVID-19 effects on brain

March 9, 2022
By Nuala Moran
An analysis of brain scans of participants in the UK Biobank has shown there are significant differences between the condition of the brain before and after mild COVID-19 infection. These included a reduction in overall brain size, reduction in grey matter thickness in the orbitofrontal cortex and hippocampal gyrus, and changes in markers of tissue damage in regions functionally connected to the primary olfactory cortex. Infected participants also showed, on average, a larger cognitive decline than participants who had not contracted COVID-19.
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Natural killer cell
ESMO TAT

Heating cold tumors one subtype, and one cell type, at a time

March 8, 2022
By Anette Breindl
“In 2015, when I started in this field…. people considered breast cancer a cold tumor,” Marleen Kok told the audience at the European Society of Medical Oncology’s 2022 Targeted Anticancer Therapy meeting (ESMO TAT). But the sensitivity of breast cancer to immunotherapy, or lack thereof, is “not a black and white phenomenon.”
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Lymph nodes

Genetic findings pave way to treatment of lymph disorder

March 7, 2022
By John Fox
An international collaboration led by scientists at The University of South Australia, SA Pathology in Adelaide, and the de Duve Institute, University of Louvain, Belgium, has discovered biallelic MDFIC pathogenic variants underlying the severe lymphatic disorder, central conducting lymphatic anomaly (CCLA), in seven people from six separate families.
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Cancer cell destruction by nanoparticles

Engineered retinal cells stare daggers at peritoneal tumors

March 4, 2022
By Anette Breindl
By using engineered retinal pigment epithelial cells to deliver IL-2 into the tumor microenvironment, investigators at Rice University eradicated ovarian and colorectal tumors in mouse models, and elicited T-cell responses after implantation in primates.
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Stomach and esophagus

Infection in thymus causes autoimmunity in stomach

March 3, 2022
By Anette Breindl
In the February 28, 2022, issue of the Journal of Experimental Medicine, researchers from Washington University in St. Louis have demonstrated that in a mouse model, there is a causal link between murine roseolovirus and autoimmune gastritis.
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Viruses-infecting-neurons.png

Neuropathy may unify disparate long COVID symptoms

March 2, 2022
By Anette Breindl
Researchers from Massachusetts General Hospital have identified peripheral neuropathy in more than half of a group of long COVID patients, suggesting that it may be a mechanism that contributes to multiple, seemingly disparate, long COVID symptoms.
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Neurons

Study finds potential entry points to Huntington's therapy

March 1, 2022
By John Fox
A Chinese study led by researchers at Fudan University in Shanghai has described a novel strategy to target the "undruggable" mutant Huntingtin protein by screening for compounds that directly bind to the 'undruggable' target and rescue disease-relevant phenotypes.
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Skeletal system

Study identifies potential new bone disease target

Feb. 28, 2022
By John Fox
Scientists at Osaka University have discovered that intercellular communication via extracellular vesicles from osteoblasts, cells that are specialized for laying down new bone, is a key factor for the transition from bone formation to resorption via a microRNA (miRNA)-mediated mechanism.
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