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Microscopic visualization of a cancerous cell

EBV antibodies put to good use through retargeting

Feb. 18, 2022
By Anette Breindl
Researchers at Inserm have developed a method to direct pre-existing antibodies toward new targets. Their bimodular fusion proteins could be a broadly useful method for expanding access to antibody therapy. In a study that appeared in the Feb. 11, 2022, issue of Science Advances, the teams showed that antibodies to Epstein-Barr virus (EBV), which are present in 95% of the global population, could be redirected to a target cell of their choosing by fusing an EBV antigen to a cellular targeting ligand.
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HIV-infected T cells

CROI 2022: Predicting the future to get ahead of viruses

Feb. 17, 2022
By Anette Breindl
Broadly neutralizing antibodies are one of the most powerful weapons against HIV. And like everything that is effective in the fight against HIV, they are hard to come by.
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Global vaccine.png
CROI 2022

Still no HIV vaccine, but optimism fueled by ‘amazing’ science, ‘astounding’ technology

Feb. 16, 2022
By Anette Breindl
Barely more than two years into the COVID-19 pandemic, there are five approved vaccines against SARS-CoV-2 available in the U.S. Forty years into the HIV pandemic, there are none. That contrast was repeatedly made by speakers at the 2022 Conference on Retroviruses and Opportunistic Infections (CROI).
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Ebola virus

Persistent Ebolavirus in brain seeds relapses

Feb. 16, 2022
By W. Todd Penberthy
In the Feb. 9, 2022, issue of Science Translational Medicine, investigators reported the anatomical location in which the Ebola virus was hiding and persisting in nonhuman primates had otherwise appeared to have been cured by monoclonal therapy prior to the relapse.
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HIV infected cell

CROI 2022: HIV remission – with transplant, without GVHD – brings hope and insights

Feb. 15, 2022
By Anette Breindl
At the 2022 Conference on Retroviruses and Opportunistic Infections (CROI), investigators reported on a fourth patient who has achieved HIV remission after a stem cell transplant. The patient is the first woman and the first mixed-race person to achieve HIV remission through a transplant procedure. In 2017, she was transplanted with cord blood stem cells lacking a functional CCR5 receptor, which prevents HIV from entering cells.
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COVID-19 research illustration

Studies at CROI show interferons' complex effects, therapeutic potential

Feb. 15, 2022
By Anette Breindl
It's neither a retrovirus nor an opportunistic infection. But of course, SARS-CoV-2 has a prominent place at the table at the 2022 Conference on Retroviruses and Opportunistic Infections (CROI) – starting with the fact that COVID-19 has again forced the conference to go virtual.
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Microscope image of SARS-CoV-2

T-cell evasion is one pressure shaping SARS-CoV-2 evolution

Feb. 14, 2022
By Nuala Moran
The overwhelming focus of research into the cellular immune response to SARS-CoV-2 has been investigating the reaction of vaccinated people, in an effort to establish correlates of protection required to fight off infection. But with a majority in many African and Asian countries still unvaccinated, it also is important to understand the natural cellular immune response, and to track the emergence of SARS-CoV-2 variants with the potential to escape immunity in these populations.
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No pain, health gain with biochemical mimicry of caloric restriction?

Feb. 11, 2022
By Anette Breindl
Using a mix of clinical and animal studies, researchers at Yale University have identified an enzyme whose decreased activity appears to be behind some of the beneficial effects of caloric restriction. They published their work in the February 11, 2022, issue of Science.
Read More
Prostate cancer cells

Advanced prostate cancer antibody successful in dogs

Feb. 10, 2022
By John Fox
A Japanese study has shown that targeting the chemokine receptor CCR4 using treatment with the monoclonal antibody mogamulizumab (Poteligeo, Kyowa, Amgen) depleted immune regulatory T cells and significantly improved survival in a canine model of advanced prostate cancer.
Read More
Female holding head with medicine on table

From populations to cells, long COVID coming into focus

Feb. 9, 2022
By Anette Breindl
Studies published this week have introduced a consensus-based definition of long COVID-19 in children and young persons, narrowing its prevalence estimates, which have been wildly divergent. Long COVID rates for adults are still unclear, but a recent meta-analysis estimated that between one third and two thirds of adult COVID-19 patients who had severe acute disease develop symptoms of long COVID.
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