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Ebola virus

Persistent Ebolavirus in brain seeds relapses

Feb. 16, 2022
By W. Todd Penberthy
In the Feb. 9, 2022, issue of Science Translational Medicine, investigators reported the anatomical location in which the Ebola virus was hiding and persisting in nonhuman primates had otherwise appeared to have been cured by monoclonal therapy prior to the relapse.
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HIV infected cell

CROI 2022: HIV remission – with transplant, without GVHD – brings hope and insights

Feb. 15, 2022
By Anette Breindl
At the 2022 Conference on Retroviruses and Opportunistic Infections (CROI), investigators reported on a fourth patient who has achieved HIV remission after a stem cell transplant. The patient is the first woman and the first mixed-race person to achieve HIV remission through a transplant procedure. In 2017, she was transplanted with cord blood stem cells lacking a functional CCR5 receptor, which prevents HIV from entering cells.
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COVID-19 research illustration

Studies at CROI show interferons' complex effects, therapeutic potential

Feb. 15, 2022
By Anette Breindl
It's neither a retrovirus nor an opportunistic infection. But of course, SARS-CoV-2 has a prominent place at the table at the 2022 Conference on Retroviruses and Opportunistic Infections (CROI) – starting with the fact that COVID-19 has again forced the conference to go virtual.
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Microscope image of SARS-CoV-2

T-cell evasion is one pressure shaping SARS-CoV-2 evolution

Feb. 14, 2022
By Nuala Moran
The overwhelming focus of research into the cellular immune response to SARS-CoV-2 has been investigating the reaction of vaccinated people, in an effort to establish correlates of protection required to fight off infection. But with a majority in many African and Asian countries still unvaccinated, it also is important to understand the natural cellular immune response, and to track the emergence of SARS-CoV-2 variants with the potential to escape immunity in these populations.
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No pain, health gain with biochemical mimicry of caloric restriction?

Feb. 11, 2022
By Anette Breindl
Using a mix of clinical and animal studies, researchers at Yale University have identified an enzyme whose decreased activity appears to be behind some of the beneficial effects of caloric restriction. They published their work in the February 11, 2022, issue of Science.
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Prostate cancer cells

Advanced prostate cancer antibody successful in dogs

Feb. 10, 2022
By John Fox
A Japanese study has shown that targeting the chemokine receptor CCR4 using treatment with the monoclonal antibody mogamulizumab (Poteligeo, Kyowa, Amgen) depleted immune regulatory T cells and significantly improved survival in a canine model of advanced prostate cancer.
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Female holding head with medicine on table

From populations to cells, long COVID coming into focus

Feb. 9, 2022
By Anette Breindl
Studies published this week have introduced a consensus-based definition of long COVID-19 in children and young persons, narrowing its prevalence estimates, which have been wildly divergent. Long COVID rates for adults are still unclear, but a recent meta-analysis estimated that between one third and two thirds of adult COVID-19 patients who had severe acute disease develop symptoms of long COVID.
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Stomach and intestine

For pain signaling, endocytosis is not the end

Feb. 9, 2022
By Anette Breindl
Researchers at New York University have demonstrated that protease-activated receptor 2 (PAR2) on epithelial cells of the colon continued after they were trafficked from the cell membrane.
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Kidneys

Three components enable 3D kidney tissue from mouse embryonic stem cells

Feb. 8, 2022
By Tamra Sami
Japanese researchers have created complex 3D kidney organoids that could lead the way to better kidney research and even artificial kidneys for human transplant.
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Cross-section of brain

Selenium mediates neurogenesis after hippocampal injury

Feb. 7, 2022
By John Fox

An international collaborative study led by Australian scientists at the University of Queensland in Brisbane has demonstrated that dietary selenium supplementation mediates exercise-induced adult neurogenesis and reverses learning deficits induced by hippocampal injury and aging in mice.


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