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Stomach and intestine

To reach their full potential, stem cells need right environment

July 15, 2022
By Anette Breindl
Using long-term in vivo imaging combined with computational modeling, a multinational team of researchers has gained new insights into what makes potential stem cells able to fulfill their role functionally.
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Cancer cells under magnifying glass

KDM4B enzyme inhibitor tested for aggressive rhabdomyosarcoma

July 14, 2022
By Mar de Miguel
An effective treatment could be found for one of the most aggressive pediatric cancers, alveolar rhabdomyosarcoma (aRMS).
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Tau neuron illustration

"Master sites" trigger cascade of tau phosphorylation in Alzheimer's disease

July 13, 2022
By Tamra Sami
Researchers have discovered how the tau protein turns from a normal to a disease state in Alzheimer's disease (AD) and have shown how the discovery could potentially deliver a therapeutic target.
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Colorful illustration of the heart

Tenaya sets out rationale for targeting HDAC6 in heart failure

July 12, 2022
By Cormac Sheridan
Several genetic studies in a range of model organisms have pointed to an important role for the B-cell lymphoma 2 (BCL2)-associated athanogene 3 (BAG3) gene in the maintenance of cardiac function.
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Sickle cell disease

Limitations of certain mouse models for sickle cell research highlighted

July 8, 2022
By Helen Albert
Research carried out by a team at St. Jude Children's Research Hospital in Memphis highlights the importance of carefully assessing the mouse model you plan to use before starting preclinical medical research.
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Cancer cell, DNA illustration

BRCA1 methylation, mutation portend different response to chemotherapy

July 7, 2022
By Anette Breindl
No matter how they come about, functional impairments in the DNA repair protein BRCA1 will hamper cells' ability to repair their genome, and increase the chances that a cell will become cancerous. However, researchers from the Jackson Laboratory for Genomic Medicine reported in the July 6, 2022, issue of Science Translational Medicine that reduced BRCA1 activity that was due to methylation of its promoter differed from BRCA1 mutation in terms of its response to platinum chemotherapy.
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Cross section of brain

Postmortem brain study gives clues to long COVID

July 6, 2022
By Anette Breindl
SARS-CoV-2 infection caused damage to brain blood vessels via a cascade of immune system reactions that was most likely initiated by antibody-dependent cytotoxicity, researchers from the National Institute of Neurological Disorders and Stroke reported in the July 5, 2022, online issue of Brain.
Read More
RNA

RNA-binding protein helps colon cancer cells persist

July 5, 2022
By Anette Breindl
Researchers have identified an RNA-binding protein that played a role in colon cancer relapse, offering new insights into how cells persist in the presence of chemotherapy.
Read More
Researchers in lab demonstrating technology

New monitor may help surgeons detect blood clots faster

July 1, 2022
By David Godkin
The University of Central Florida (UCF) and Orlando Health are testing new medical technology designed to identify blood clots more quickly in surgery. The monitoring device consists of a small optical fiber that uses red blood cells to track the process of blood coagulation in patients so doctors can watch for life threatening blood clot formation.
Read More
Cancer cells under magnifying glass

Tumors might be nudged to more treatable state

July 1, 2022
By Anette Breindl
Researchers at the Institute for Cancer Research have demonstrated that in pancreatic tumors, the balance between a more aggressive mesenchymal and a less aggressive epithelial state is constantly in flux, depending on an interplay of different regulatory proteins.
Read More
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