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Illustration of ecDNA inheritance in cancer

Extrachromosomal DNA acts as joker for cancer cells

Nov. 13, 2024
By Mar de Miguel
Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up the tumors’ sleeve to adapt and evade attack. Three simultaneous studies in the journal Nature lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them.
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3D illustration of brain cancer

Quiescent, but not quiet, cancer stem cells in glioblastoma relapse

Nov. 13, 2024
By Mar de Miguel
Six main cell types form glioblastomas, the most aggressive brain cancer due to its high rate of recurrence. Of these six, quiescent cancer stem cells are responsible for resistance to therapy and the reappearance of the tumor, according to a study that identified the six groups and highlighted the importance of these stem cells for the design of more effective therapies.
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Illustration of ecDNA inheritance in cancer

Extrachromosomal DNA acts as joker for cancer cells

Nov. 12, 2024
By Mar de Miguel
Cancer therapies can eliminate specific tumors based on their genetic content. However, some cancer cells survive. How do they do it? Part of the answer lies in extrachromosomal DNA (ecDNA), an ace up the tumors’ sleeve to adapt and evade attack. Three simultaneous studies in the journal Nature lay all the cards on the table, revealing ecDNAs’ content, their origin, their inheritance, their influence in cancer, and a way to combat them.
Read More
Illustration of Microglia cells (red) in Alzheimer´s disease
Neurology/psychiatric

Less microglia activity may improve APOE4’s effect in Alzheimer’s

Nov. 8, 2024
By Mar de Miguel
Reducing microglial activity in the presence of apolipoprotein E4 (APOE4) has uncovered a mechanism associated with the deposition of misfolded amyloid and tau in a novel mouse model of Alzheimer’s disease. By transplanting human neurons into the mouse brain and eliminating the mouse microglia, scientists at the Gladstone Institutes in San Francisco observed that amyloid and tau deposition was reduced. These results support therapeutic strategies that target APOE4 and microglia.
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Endometriosis
Endocrine/metabolic

Blocking CGRP in endometriosis: two birds with one stone?

Nov. 7, 2024
By Coia Dulsat
Researchers at Harvard Medical School have found that blocking the neuron-released peptide CGRP decreases pain sensitivity and reduces lesion size in endometriosis. Endometriosis is a painful, steroid-dependent inflammatory condition in which tissue similar to that of the endometrial lining grows and establishes outside the uterine mucosa.
Read More
AI-generated digital horse illustration
Cancer

Gene editing is Trojan horse of cancer immunotherapy

Nov. 4, 2024
By Mar de Miguel
Gene editing strategies, from epigenetic engineering to cell reprogramming and genetic vaccines, are accelerating the development of new therapies that awaken the immune system to treat cancer, as presented last month in Rome at the 31st Annual Congress of the European Society of Gene and Cell Therapy (ESGCT). Some of these advances are taking advantage of the conditions of the tumor microenvironment, where cancer cells coexist with immune cells, microorganisms and blood vessels.
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Brain cancer illustration
Cancer

ESGCT 2024: Steps forward in gene and cell therapies for brain tumors

Oct. 29, 2024
By Mar de Miguel
Scientists from different laboratories around the world have presented the latest advances in research into malignant brain tumors at the 31st Annual Congress of the European Society of Gene and Cell Therapy (ESGCT), which is being held Oct. 22 to 25 in Rome.
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Pill in immersive interface

BioFuture 2024: Where AI leads, developers must follow

Oct. 28, 2024
By Lee Landenberger
Artificial intelligence (AI) is enabling a foundational understanding of drug discovery that is changing the typical pathway used in modern development. The powerful new computer technology will lead developers from conducting hypothesis-driven research to more and deeper data-driven research, Manolis Kellis, professor at the Computer Science and Artificial Intelligence Laboratory at the Massachusetts Institute of Technology (MIT) and an associate member at the Broad Institute of MIT and Harvard University, told those attending the BioFuture 2024 conference in New York on Oct. 28.
Read More
Illustration of human body composed of molecules
Cancer

Using black hole study methods, digital twins take aim at the patient black box

Oct. 25, 2024
By Xavier Bofill Bruna
Currently, cancer therapy trial-and-error methodology is inefficient and unsustainable. Oncology is the worst therapeutic area for drug trial success; only 3.4% of drugs that enter phase I end up being FDA approved, and 57% fail due to poor drug efficacy in trials. Building tools that may aid in predicting an individual’s response to a specific therapy may help in reducing costs, guesswork, and importantly improve the outcome of patients and accelerate new drug development.
Read More
Brain cancer illustration
Cancer

ESGCT 2024: Steps forward in gene and cell therapies for brain tumors

Oct. 24, 2024
By Mar de Miguel
Scientists from different laboratories around the world have presented the latest advances in research into malignant brain tumors at the 31st Annual Congress of the European Society of Gene and Cell Therapy (ESGCT), which is being held Oct. 22 to 25 in Rome.
Read More
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