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Cancer cells under magnifying glass
Cancer

ESMO 2024: For T-cell target antigens, lots to see, but what to show?

Sep. 16, 2024
By Anette Breindl
Metastatic solid tumors may be curable now. Among the most profound results presented over the weekend at the European Society for Medical Oncology (ESMO) 2024 Congress were the 10-year data from the Checkmate-067 and Keynote-006 trials, the phase III trials that tested Opdivo (nivolumab, Bristol Myers Squibb Co.) and Keytruda (pembrolizumab, Merck & Co. Inc.) as first-line agents in advanced or metastatic melanoma.
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Oscar-Wilde-illustration.jpg
Aging

Updating Oscar Wilde’s visions of rejuvenation at ARDD 2024

Sep. 13, 2024
By Mar de Miguel
Immortality and eternal youth have been the stuff of myths and legends from ancient times on. Now, in the 21st century, real studies of current medicine could be applied to repair tissues and organs damaged by age. During the 11th Aging Research & Drug Discovery (ARDD) Meeting held at the University of Copenhagen at the end of August, scientists explained the molecular keys of rejuvenation, as many artists imagined in the past.
Read More
Graph showing voltage of cell membrane's change over time
Cancer

Focusing on tumor cells brings insights into cancer neuroscience

Sep. 12, 2024
By Anette Breindl
By looking at the electrical activity of tumor cells, rather than the neurons that innervate them, investigators at Baylor College of Medicine have added both basic and translational insights to the emerging field of cancer neuroscience. In their studies, which were published in Cancer Cell on Sept. 5, 2024, the researchers identified the cell of origin for IDH-mutated gliomas.
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Profile view of the human head highlighting the eye
Ocular

Partial epigenetic reprogramming to treat ischemic optic neuropathy

Sep. 12, 2024
By Mar de Miguel
A novel gene therapy that leads to cellular rejuvenation could restore vision after non-arteritic anterior ischemic optic neuropathy (NAION) and glaucoma. The technique is based on a reprogramming process that reverses the epigenetic DNA alterations caused by aging. Preclinical studies in glaucoma mice and nonhuman primates (NHP) models for this stroke-like disorder that affects the eye, showed an improvement of vision and restoration of the damaged axons of the optic nerve.
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Graph showing voltage of cell membrane's change over time
Cancer

Focusing on tumor cells brings insights into cancer neuroscience

Sep. 10, 2024
By Anette Breindl
By looking at the electrical activity of tumor cells, rather than the neurons that innervate them, investigators at Baylor College of Medicine have added both basic and translational insights to the emerging field of cancer neuroscience. In their studies, which were published in Cancer Cell on Sept. 5, 2024, the researchers identified the cell of origin for IDH-mutated gliomas.
Read More
Oscar-Wilde-illustration.jpg
Aging

Updating Oscar Wilde’s visions of rejuvenation at ARDD 2024

Sep. 6, 2024
By Mar de Miguel
Immortality and eternal youth have been the stuff of myths and legends from ancient times on. Now, in the 21st century, real studies of current medicine could be applied to repair tissues and organs damaged by age. During the 11th Aging Research & Drug Discovery (ARDD) Meeting held at the University of Copenhagen at the end of August, scientists explained the molecular keys of rejuvenation, as many artists imagined in the past.
Read More
AI-generated illustration of muscular man running

ARDD 2024: Age without disease, exercise muscles and win $111M

Sep. 3, 2024
By Mar de Miguel
Aging is part of the life cycle and, although the effects are not manifest until after adulthood, it actually occurs from birth. The concept of senescence has traditionally been associated with aging. However, an embryo has senescent cells. In that case, what is aging, how can it be measured, and from what point in the life cycle?
Read More
Hourglass on glowing circuit board, symbolizing time and technology
Aging

ARDD 2024: Back to the future in the times of aging research

Aug. 29, 2024
By Mar de Miguel
Since the publication of The Hallmarks of Aging in 2013, aging research has exploded. The field now has more than 300,000 articles on the biological signals of the effect of time on the body. What would Marty McFly, the legendary character from the Back to the Future saga who traveled with his DeLorean time machine from the ‘80s to the ‘50s, think if he visited 2024 and saw laboratories experimenting with techniques to turn back the biological clocks of cells or increase the lifespan of rejuvenated mice?
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Hair follicle containing phagocytic stem cells
Dermatologic

Stem cells eat dead cells to ensure tissue integrity

Aug. 28, 2024
By Mar de Miguel
Phagocytosis – eliminating millions of dead cells every day – requires specialized cells such as macrophages, the true professionals, which migrate to engulf waste and dying cells.
Read More
Hair follicle containing phagocytic stem cells
Dermatologic

Stem cells eat dead cells to ensure tissue integrity

Aug. 27, 2024
By Mar de Miguel
Phagocytosis – eliminating millions of dead cells every day – requires specialized cells such as macrophages, the true professionals, which migrate to engulf waste and dying cells. But they are not the only ones that can perform this task, as scientists at Howard Hughes Medical Institute (HHMI) discovered when they investigated hair follicle stem cells (HFSCs), a tissue in constant regeneration, to clarify how dying cells are detected and cleared in the epithelium and the mesenchyme.
Read More
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