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BioWorld - Saturday, September 30, 2023
Home » Topics » Science

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Mosaic illustration of a mouse
Neurology/Psychiatric

Genetic editing of individual cells points to late targets for developmental disorders

Sep. 28, 2023
By Mar de Miguel
No Comments
A new gene editing method uses the CRISPR technique to modify the cells of an organ in vivo, creating a mosaic used to identify the effects of each altered gene. Scientists from the Swiss Federal Institute of Technology (ETH) in Zürich developed this technology called AAV-Perturb-seq, based on adeno-associated virus (AAV) to target, edit and analyze single-cell genetic perturbations.
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AI generated illustration of a brain on fire
Neurology/Psychiatric

Newco news: Arialys has autoimmune solution to psychosis problem

Sep. 27, 2023
By Anette Breindl
No Comments
Arialys Therapeutics Inc. launched this month with $58 million in seed funding, an experimental compound it is developing for autoimmune encephalitis and autoimmune psychosis, and high aspirations for its field. “Yes, I want to treat these patients, I want these patients to have a better life. But I also want drug discovery and development folks to think differently about discovering new drugs for the CNS,” Jay Lichter told BioWorld.
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Art concept for gene therapy research

Machine learning tool Alphamissense analyzes human mutations to predict diseases

Sep. 19, 2023
By Mar de Miguel
No Comments
Proteome analysis with artificial intelligence has made it possible to create a catalog of all possible missense mutations in the human genome to predict diseases.
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Art concept for gene therapy research
Genetic/Congenital

Machine learning tool Alphamissense analyzes human mutations to predict diseases

Sep. 19, 2023
By Mar de Miguel
No Comments
Proteome analysis with artificial intelligence has made it possible to create a catalog of all possible missense mutations in the human genome to predict diseases. The new Alphamissense tool from the technology company Google Deepmind, available online, will allow scientists to refine diagnoses and design more tailored treatment strategies for patients suffering from pathologies associated with these variants.
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Illustration of Alzheimer’s in the brain.
Neurology/Psychiatric

Study identifies cause of death for Alzheimer’s neurons

Sep. 18, 2023
By Anette Breindl
No Comments
By creating a new mouse model of Alzheimer’s disease that better recapitulated how the disease plays out in humans, investigators at KU Leuven have gained new insights into how amyloid plaques, tau tangles and neuronal death are related at the molecular level.
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Ian Wilmut and Dolly the Sheep

Cloning pioneer Ian Wilmut dies at 79

Sep. 12, 2023
No Comments
Scientist Ian Wilmut, who led a team from Scotland’s Roslin Institute and biotech company PPL Therapeutics plc to clone Dolly the Sheep in 1996, died on Sept. 10 at age 79. Dolly was the first mammal cloned from an adult cell taken from the mammary gland of a 6-year-old Finn Dorset sheep and an egg cell from a Scottish Blackface sheep.
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Central nervous system
Neurology/Psychiatric

Methodological, target breadth begets optimism for movement disorder progress

Aug. 29, 2023
By Anette Breindl
No Comments
“I am not a fortune teller, nor am I a gambler. I will make no bets,” Lorraine Kalia told the audience at the 2023 International Congress of Parkinson’s Disease and Movement Disorders. “But I am optimistic.” At the meeting, which is being held in Copenhagen this week, Kalia, who is a scientist at Toronto Western Hospital’s Krembil Brain Institute and at the University of Toronto’s Tanz Centre for Research in Neurodegenerative Diseases, was giving an overview of “Emerging targets in the clinic” in a plenary session on “Therapeutic strategies for the future.”
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Cancer research illustration
Cancer

Multiple KRAS targeting strategies paving way for combination therapies

Aug. 25, 2023
By Mar de Miguel
No Comments
KRAS-mutated tumors were once untreatable. In fact, KRAS was something of a poster child for so-called undruggability. Several laboratories are investigating strategies to address other mutations and uses beyond non-small cell lung cancer (NSCLC) and colorectal cancer. If you can't bind KRAS to block it, use a glue or combine multiple weapons. This is the idea behind two new approaches that target cancers caused by this proto-oncogene.
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Clovibactin art concept
Infection

Cage fight could make for resistance-resistant antibiotic

Aug. 23, 2023
By Nuala Moran
No Comments
A newly discovered antibiotic has been shown to block the synthesis of bacterial cell walls via immutable targets, raising the prospect of a class of drugs that will not lose effect through the development of antimicrobial resistance. Clovibactin, isolated from soil bacteria, targets the cell wall precursor molecules lipid II, lipid III and undecaprenyl phosphate (C55PP), all of which have a pyrophosphate group in common.
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3D rendered illustration of the anatomy of a cancer cell
Cancer

Pan-cancer studies take pan-oramic view on proteogenomics

Aug. 22, 2023
By Mar de Miguel
No Comments
The vast variety of tumors makes each cancer a world. For researchers, understanding the commonalities and divergences in their molecular underpinnings could help find successful treatments. Scientists from the Clinical Proteomic Tumor Analysis Consortium (CPTAC) have addressed these similarities and differences in 10 different types of cancer with two proteogenomic studies to unravel the genes that lead to cancer and the galaxy of interactions that regulate them.
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