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Lung cancer illustration
Cancer

GUK1 is metabolic gate in ALK-driven lung cancer

Feb. 19, 2025
By Xavier Bofill Bruna
Using ALK+ lung cancer patient-derived cell lines, researchers have performed phosphoproteomic screening and identified guanylate kinase 1 (GUK1) as a TKI sensitive metabolic molecule in ALK-driven lung cancer. They reported their results online in Cell on Feb. 6, 2025.
Read More
US flag with microscope

Trump administration an existential threat to science, warns AAAS chief

Feb. 14, 2025
By Nuala Moran
The scientific establishment has launched a fight back against the Trump administration and the slew of executive orders that threaten to dismantle research funding, with a warning that the next month could be critical for the future of U.S. science.
Read More
Cancer cells under magnifying glass
Cancer

Insights into extracellular matrix are metastasis map

Feb. 14, 2025
By Nuala Moran
New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ from ECM. The findings will make it easier to identify tumors that are likely to metastasize at an early stage.
Read More
Cancer cells under magnifying glass
Cancer

Insights into extracellular matrix are metastasis map

Feb. 14, 2025
By Nuala Moran
New research has uncovered a complex interplay between extracellular matrix (ECM) structure and the transcriptional responses of cancer cells, showing how they alter their gene expression to ‘escape’ from ECM. The findings will make it easier to identify tumors that are likely to metastasize at an early stage.
Read More
Brain tumor illustration
Cancer

OLIG2 inhibitor shows promise in treatment-resistant brain tumors in preclinical models

Feb. 11, 2025
By Tamra Sami
Researchers from the QIMR Berghofer Medical Research Institute in Queensland, Australia and Emory University have shown that a potential new targeted therapy for childhood brain cancer was effective in infiltrating and killing tumor cells in mouse models.
Read More
DNA, RNA concept art.
Drug design, drug delivery & technologies

Genomic study paves way for multimorbidity treatments

Feb. 10, 2025
By Nuala Moran
A large-scale study cross-referencing genomic data from multiple sources with primary care health records has identified genetic overlaps in 72 chronic diseases, opening the way for a more holistic approach to researching, treating and preventing multimorbidity.
Read More
DNA, RNA concept art.

Genomic study paves way for multimorbidity treatments

Feb. 7, 2025
By Nuala Moran
A large-scale study cross-referencing genomic data from multiple sources with primary care health records has identified genetic overlaps in 72 chronic diseases, opening the way for a more holistic approach to researching, treating and preventing multimorbidity.
Read More
Cancer cell, DNA illustration

Targeting translation could be novel way to fight Myc, other oncogenes

Feb. 5, 2025
By Anette Breindl
Researchers at the University of California at San Francisco have identified an RNA-binding protein that increased the translation of Myc mRNA. The authors wrote that their work, which was published online in Nature Cell Biology on Feb. 4, 2025, “transforms the understanding of the translational code in cancer and illuminates therapeutic openings to target the expression of oncogenes.”
Read More
Photo of bird, H5N1 virus
Infection

Antibody prevents severe bird flu in macaques

Feb. 3, 2025
By Mar de Miguel
Scientists at the University of Pittsburgh have tested a broadly neutralizing antibody that binds the stem of a protein against H5N1 avian influenza, which prevented severe disease in nonhuman primates and was effective for at least 8 weeks. The scientists remark on the potential of the design developed by Astrazeneca plc against a possible outbreak of the influenza A virus.
Read More
Immune cells (red) migrate to the pancreas and stimulate glucagon-producing cells (orange)
Endocrine/metabolic

Neurons send immune cells to the pancreas to regulate glucose

Jan. 30, 2025
By Mar de Miguel
The liver and pancreas are the main actors in glucose metabolism, but not the only ones. Muscles, adipose tissue and the brain play different roles. However, the prize for the best new actor in glucagon production goes to the innate lymphoid cells (ILCs), which, according to a study published in Science, respond to intestine neuron signals traveling to the pancreas to control glucose.
Read More
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