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BioWorld - Saturday, September 30, 2023
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Brain and DNA

New genes and mutations linked to autism

Aug. 22, 2022
By Mar de Miguel
No Comments
Two large-scale studies provide new data on genes, inherited variations, and de novo mutations associated with autism spectrum disorder. Some of them are also associated with other neurological conditions, like developmental delay, or schizophrenia.
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Amyloid plaque on nerve cell

Fusion protein reduces amyloid with less inflammation

Aug. 19, 2022
By Mar de Miguel
No Comments
A fusion protein removed beta-amyloid plaque without producing the neurotoxic inflammation associated with other treatments, such as aducanumab immunotherapy. It is based on the alphaA Beta-Gas6 fusion protein developed in a mouse model of Alzheimer's disease by a team of researchers at The Korea Advanced Institute of Science and Technology in South Korea.
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From p53 loss to cancer, a series of unfortunate events

Aug. 18, 2022
By Mar de Miguel
No Comments
The development of cancer after p53 inactivation is determined by a series of genomic changes that occur in four steps. The loss of heterozygosity of TP53 (the gene encoding p53 in humans, named Trp53 in mice) is followed by an accumulation of deletions, genome doubling, and the emergence of gains and amplifications. In a study published in the August 17, 2022, issue of Nature, researchers have further observed that these four phases of genomic evolution are associated with specific histological stages before and after the malignant condition developed.
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RNA

Antisense oligonucleotides targeting LINE-1 RNA could be used to treat premature aging

Aug. 17, 2022
By Nuala Moran
No Comments
Scientists have discovered an RNA-based mechanism that is involved in core hallmarks of a number of accelerated aging conditions and shown that therapies targeting this RNA reverses some of these hallmarks in human cells and extend life spans in mouse models.
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Marco Caffio working with Gii technology

Scottish researchers team up to develop liver transplant test

Aug. 12, 2022
By Catherine Longworth
No Comments
Integrated Graphene Ltd. is partnering with a team of scientists at the University of Edinburgh to develop a point-of-care biomedical test for liver transplants. The Sensibile project team is working to develop a prototype electrochemical biosensor that can detect biliary complications’ biomarkers in donor livers. Sterling, Scotland-based Integrated Graphene’s 3D graphene foam electrode will help to assess the viability of the biliary compartment, and the quality of the donor liver prior to transplantation.
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Neuron

New screening platform reveals neurodegeneration drug targets in microglia

Aug. 12, 2022
By Nuala Moran
No Comments
As the resident innate immune cells of the brain, microglia are emerging as key drivers of neurological diseases, but as yet there is no systematic way of exploring their potential as drug targets.
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CAR T cell attacking cancer cells

New method developed to produce generic CAR T cells at scale

Aug. 12, 2022
By Mar de Miguel
No Comments
A new method has been devised to produce generic chimeric antigen receptor (CAR) T cells at scale by directing induced pluripotent stem cells to differentiate into mature T cells in vitro. The generic T cells can then be engineered to express a range of different chimeric antigen receptors.
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Cancer cells under magnifying glass

Metastasizing melanoma cells hijack gene involved in development of the nervous system

Aug. 11, 2022
By Nuala Moran
No Comments
Scientists at the Institute of Cancer Research in London have discovered that melanoma cells spread by harnessing a gene normally involved in the development of the nervous system.
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HIV infected cell

AIDS 2022: Scientists report progress in understanding how to eliminate latent HIV reservoirs

Aug. 10, 2022
By Mar de Miguel
No Comments
Researchers around the world are making advances in understanding how HIV becomes latent and seeking out vulnerabilities that could provide routes to targeting reservoirs and eliminating them.
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Optogenetics illustration

Researchers reprogram stem cells to uncover new genetic signatures of age-related AMD

Aug. 9, 2022
By Tamra Sami
No Comments
Researchers are closer to better diagnosing and treating age-related macular degeneration (AMD) after discovering new genetic signatures of the disease by reprogramming stem cells to generate high-resolution disease models.
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