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BioWorld - Sunday, September 24, 2023
Home » Topics » Science

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Fat targeting illustration
Endocrine/Metabolic

Nanomaterial allows location-specific fat targeting

Dec. 13, 2022
By Anette Breindl
No Comments
The positively charged nanoparticle polyamidoamine generation 3 (P-G3) can be specifically targeted to either visceral or subcutaneous fat, and affects both types of fat in different ways, researchers from Columbia University reported in two papers recently published.
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Fat targeting illustration
Endocrine/Metabolic

Nanomaterial allows location-specific fat targeting

Dec. 7, 2022
By Anette Breindl
No Comments
The positively charged nanoparticle polyamidoamine generation 3 (P-G3) can be specifically targeted to either visceral or subcutaneous fat, and affects both types of fat in different ways, researchers from Columbia University reported in two papers recently published. The studies, published online in Nature Nanotechnology on Dec. 1, 2022, and in Biomaterials on Nov. 28, 2022, are both “a conceptual advance” and “quite amenable to translation,” co-corresponding author Kam Leong told BioWorld.
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Neurons and amyloid plaques

Amyloid plaques recast as cause of neural network dysfunction

Dec. 6, 2022
By Anette Breindl
No Comments
Researchers have identified a link between amyloid plaques and dysfunctional neuronal conduction in animal models of Alzheimer’s disease (AD). Their study, which was published in the Dec. 1, 2022, issue of Nature, suggests new ways to think about AD, as well as badly needed potential alternatives to plaque removal to fight the disease.
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Illustration of the spike glycoprotein structure of SARS-CoV and linoleic acid molecules.
Infection

Conserved binding pocket is net positive for deadly coronavirus strains

Dec. 5, 2022
By Anette Breindl
No Comments
Investigators at the University of Bristol and Biognos AB have identified a structural feature that distinguished the deadly coronavirus strains from harmless, common cold-causing variants. The findings, which were published in the Nov. 23, 2022, issue of Science Advances, could form the basis of universal COVID antivirals, putting an end to the endless race to deal with new variants that has so far been a necessity.
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Neurons and amyloid plaques

Amyloid plaques recast as cause of neural network dysfunction

Nov. 30, 2022
By Anette Breindl
No Comments
Researchers have identified a link between amyloid plaques and dysfunctional neuronal conduction in animal models of Alzheimer’s disease (AD). Their study, which was published in the Dec. 1, 2022, issue of Nature, suggests new ways to think about AD, as well as badly needed potential alternatives to plaque removal to fight the disease.
Read More
Scanning electron micrograph of a macrophage.
Cancer

Innate immunity can drive radiation-induced abscopal effect

Nov. 29, 2022
By Anette Breindl
No Comments
A combination of radiation therapy and CD47 blockade induced an abscopal effect in animal studies even in animals that lacked T cells, researchers reported in the Nov. 21, 2022, online issue of Nature Cancer.
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Scanning electron micrograph of a macrophage.
Cancer

Innate immunity can drive radiation-induced abscopal effect

Nov. 23, 2022
By Anette Breindl
No Comments
A combination of radiation therapy and CD47 blockade induced an abscopal effect in animal studies even in animals that lacked T cells, researchers reported in the Nov. 21, 2022, online issue of Nature Cancer. The findings are “the first demonstration of T-cell-independent abscopal response,” co-corresponding author Edward Graves told BioWorld. “We’re not trying to say that all abscopal responses are macrophage-mediated. There are plenty that require T cells,” Graves clarified. But “there is another avenue of abscopal responses that has not been reported. ... All the abscopal literature is about stimulating an adaptive response.”
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Respiratory infection
Infection

Long lung COVID gives broader insights into fibrotic lung disease

Nov. 18, 2022
By Nuala Moran
No Comments
An in-depth investigation of the underlying causes of pulmonary symptoms that in some cases persist for months following recovery from the acute stage of COVID-19 has found a distinctive proinflammatory signature in the plasma and airways of affected patients.
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Dinosaur illustration

In assessing shared genetic risk, love can look like pleiotropy

Nov. 17, 2022
By Anette Breindl
No Comments
Social scientists are well aware of the consequences of what’s called assortative mating – that is, the fact that marriages tend to occur between people who are similar in things such as interests, social status, education and wealth. Biologists, on the other hand, have tended to ignore it.
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Brain samples of people with APOE3/4 vs. APOE3/3
Neurology/Psychiatric

APOE4 allele reduces myelination in Alzheimer’s disease

Nov. 16, 2022
By Mar de Miguel
No Comments
Carrying the apolipoprotein E4 allele (APOE4), and not the APOE3 variant, is the strongest risk factor for developing Alzheimer’s disease (AD). But the underlying mechanism has remained elusive. Now, researchers at MIT and Mount Sinai have found that in brains carrying the APOE4 allele, lipid and cholesterol processes were dysregulated in oligodendrocytes and that this effect reduced myelination.
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