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Researchers develop CAR T cells tagged with bacterial enzyme that can be imaged

Nov. 18, 2019
By Stacy Lawrence
There are a pair of approved CAR T drugs, Yescarta (axicabtagene ciloleucel) from Gilead Sciences Inc. and Kymriah (tisagenlecleucel) from Novartis AG, that have been available since 2017 for a few hematological cancers including some lymphomas and leukemias. But little is known about how these engineered chimeric antigen receptor T cells that both target CD19, an antigen prevalent in the cells of many B-cell malignancies, move through the body and proliferate after they are first removed, altered, expanded in number and, finally, returned to a patient's body.
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BioWorld MedTech's Neurology Extra

Nov. 18, 2019
By Liz Hollis
Keeping you up to date on recent developments in neurology.
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Chromosomes

Bench Press for Nov. 18, 2019

Nov. 18, 2019
The discovery that thalidomide and its analogues work by inducing the degradation of transcription factors demonstrated both that protein degradation is a viable mechanism of action for therapeutic small molecules, and that it could be used to target transcription factors, which are undruggable by both biologics and traditional inhibitors.
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BioWorld MedTech's Diagnostics Extra

Nov. 15, 2019
By Meg Bryant and Anette Breindl
Keeping you up to date on recent developments in diagnostics.
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Bacteriophage attaches to bacterial cell membrane
AASLD 2019

Bacteriophage 'cocktails' can be good for the liver

Nov. 14, 2019
By Anette Breindl
BOSTON – Researchers presented data at The Liver Meeting 2019 and in Nature this week demonstrating that bacteriophages targeted to specific members of the microbiome could be useful in fighting two different liver diseases.
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BioWorld MedTech's Orthopedic Extra

Nov. 14, 2019
By Holland Johnson
Keeping you up to date on recent developments in orthopedics.
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AASLD 2019

Bacteriophage 'cocktails' can be good for the liver

Nov. 14, 2019
By Anette Breindl
BOSTON – Researchers presented data at The Liver Meeting 2019 and in Nature this week demonstrating that bacteriophages targeted to specific members of the microbiome could be useful in fighting two different liver diseases.
Read More

BioWorld MedTech's Oncology Extra

Nov. 13, 2019
By Mark McCarty and Anette Breindl
Keeping you up to date on recent developments in oncology.
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AASLD 2019

DUR-928 results: Break out the sparkling cider

Nov. 13, 2019
By Anette Breindl
BOSTON – In a late-breaking oral presentation on the last day of The Liver Meeting 2019, Durect Corp. reported results from its phase IIa trial of DUR-928 for the treatment of alcoholic hepatitis. All 19 patients enrolled in the study survived for 28 days after treatment with DUR-928 , and all but two responded to the drug as measured by Lille scores, which is used for predicting risk of death.
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BioWorld MedTech's Cardiology Extra

Nov. 12, 2019
By Liz Hollis
Keeping you up to date on recent developments in cardiology.
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