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Bench Press: BioWorld looks at translational medicine

Oct. 14, 2019
By Anette Breindl
Researchers from Columbia University have demonstrated that correcting mutations in the schizophrenia risk gene SetD1 in adult mice reversed cognitive impairments, suggesting that, like a number of other brain disorders, schizophrenia's malfunctions begin in early development, but remain in place via ongoing active processes rather than reaching a point of no return. 
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Harvard researchers test in vivo, fluorescent, synthetic biology microbiome tool with Dx potential

Oct. 14, 2019
By Stacy Lawrence
Synthetic biology is seeing rapid advances, but the medical applications have thus far remained largely elusive. But now researchers from the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School (HMS) have developed a tool that can track specific populations of bacteria in the gut of living organisms and document population changes over time.
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New small-molecule inhibitors block apoptosis in mice

Oct. 14, 2019
By John Fox
Australian researchers have developed the first potent new small-molecule inhibitors capable of blocking the activation of apoptotic cell death before it causes damage to mitochondria, they reported in a study published in the Oct. 7, 2019, issue of Nature Chemical Biology.
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'Strength in numbers', 'it only takes one' both true for neoantigens

Oct. 11, 2019
By Anette Breindl
There's a yin and yang to neoantigens, Alberto Bardelli told the audience at the 2019 annual conference of the European Society of Medical Oncology (ESMO) in Barcelona, Spain, last month. They contribute to tumorigenesis, resistance and tumor heterogeneity. But they are also often specific to tumor cells but not normal cells and "some," he said, "are actionable targets."
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‘Strength in numbers’, ‘it only takes one’ both true for neoantigens

Oct. 11, 2019
By Anette Breindl
There’s a yin and yang to neoantigens, Alberto Bardelli told the audience at the 2019 annual conference of the European Society of Medical Oncology (ESMO) in Barcelona, Spain, last month.
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Calling bias sinks CCR5 work but is 'likely unique' to variant

Oct. 10, 2019
By Nuala Moran
LONDON – A paper that raised concerns for the future health of Lulu and Nana, the world's first gene edited babies, has been fully retracted at the request of the authors, after they failed to identify a problem in data from the U.K. Biobank on which their analysis was based.
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Three win Nobel prize for their hypoxia work

Oct. 8, 2019
By Anette Breindl
William Kaelin, Peter Ratcliffe, and Gregg Semenza have jointly won the 2019 Nobel Prize "for their discoveries of how cells sense oxygen," the Nobel Assembly at Karolinska Institutet announced today.
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New machine learning approach tackles privacy, black box problems

Oct. 8, 2019
By Nuala Moran
The emerging methodology of federated learning can overcome many of the ethical and privacy obstacles preventing patient data from being pooled for analysis, according to research published this week. French-American artificial intelligence (AI) specialist Owkin Inc. has demonstrated the technique can be used to apply machine learning to datasets held at different clinical centers. In a paper published in the Oct. 7 online edition of Nature Medicine, they describe how that generated new insights into the histopathology of malignant mesothelioma.
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Three win Nobel for hypoxia work

Oct. 8, 2019
By Anette Breindl
William Kaelin, Peter Ratcliffe and Gregg Semenza have jointly won the 2019 Nobel Prize "for their discoveries of how cells sense oxygen," the Nobel Assembly at Karolinska Institutet announced Monday.
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Main function of Parkinson's gene is in inflammation

Oct. 7, 2019
By Anette Breindl
The leucine-repeat rich kinase 2 (Lrrk2) gets most of its attention in the context of Parkinson's disease (PD). Variants in Lrrk2 are a major cause of familial PD (though familial PD makes up only a small fraction of overall PD cases).
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