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Home » Topics » Science » Immunotherapy

Immunotherapy
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Cartography immunotherapy target illustratio
Newco news

Precision target discovery at forefront for immunotherapy startup Cartography

July 5, 2023
By Caroline Richards
Most drug developers working in the immunotherapy space focus on existing therapeutic targets when developing cancer drugs, optimizing ways of drugging them via engineering modalities such as CAR T-cell approaches, CRISPR editing or antibody-drug conjugates that deliver toxic payloads. The angle of one company – Cartography Biosciences – is the opposite to this. Its modus operandi is to pinpoint the immunological targets first, leveraging tools that already exist, before building therapies around them.
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Cancer

Macrophages drive invasive breast cancer

March 20, 2023
By Mar de Miguel
T cells do not have the last word in some breast cancers. According to a study from the University of Pittsburgh, the key to estrogen receptor positive (ER+) breast tumors are macrophages, not T cells, and targeting them could prevent immunotherapy failure in this type of cancer.
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Cancer

Releasing T cells from neutrophil traps restores immunotherapy in pancreatic cancer

March 16, 2023
By Mar de Miguel
The traps that neutrophils develop against microorganisms also hold T cells and prevent the success of immunotherapy in pancreatic cancer. To free the immune system from itself, scientists at the Istituto Oncologico Veneto in Italy made a key that unlocked this sticky dungeon from an antibody against arginase-1 (ARG1), an enzyme also present in the trap.
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Gastrointestinal system with ulcerative colitis.
Gastrointestinal

Rise Therapeutics to advance R-3750 immunotherapy for ulcerative colitis

Feb. 1, 2023
Rise Therapeutics LLC has received FDA clearance for its IND application to proceed with a phase I trial of R-3750, a synthetic biology-based cellular immunotherapy being developed for the treatment of inflammatory bowel disease. The phase I trial will enroll patients with mild to moderate ulcerative.
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Neutrophil and red blood cells
Cancer

Redeeming neutrophils could be anticancer approach

Jan. 27, 2023
By Mar de Miguel
Unexpected behavior of neutrophils unveiled by researchers at Stanford University could lead to a new type of immunotherapy to treat cancer. Although various studies have suggested that these cells are harmful due to their immunosuppressive characteristics, the scientists saw in them an opportunity to redirect them and eliminate tumors.
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Cancer cells under magnifying glass
Cancer

Oncogene activation during immunotherapy triggers cancer hyperprogression

Jan. 20, 2023
By Mar de Miguel
Immunotherapy, a treatment that increases the survival of cancer patients to the point of remission of the disease, can also have the opposite effect. In some patients, immune checkpoint blockade accelerates cancer. Now, researchers at the University of Michigan Medical School have discovered that the answer to this hyperprogressive disease (HPD) lies in the interconnection of the molecular pathways of interferon signaling (IFNγ), fibroblast growth factor 2 (FGF2) and the β-catenin protein.
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Cofactor Genomics expands PREDAPT study to NSCLC

Dec. 16, 2022
By Annette Boyle
Cofactor Genomics Inc. opened the non-small-cell lung cancer portion of its study of the Oncoprism test, which predicts response to immunotherapy. The Predicting Immunotherapy Efficacy from Analysis of Pre-treatment Tumor Biopsies (PREDAPT) trial will study the test’s predictive ability in 11 cancers in total.
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Human natural killer cell
Immuno-oncology

Blocking the KIR2DL5/PVR pathway boosts NK cell-based cancer immunotherapy

Dec. 7, 2022
NK cell-based cancer immunotherapy has emerged as an anticancer treatment approach and is currently being tested in clinical trials. KIR2DL5, a member of the human killer cell immunoglobulin-like receptor (KIR) family, has recently been identified as a binding partner for poliovirus receptor (PVR). However, the biology and therapeutic potential of the KIR2DL5/PVR pathway remain widely unexplored.
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Illustration of cancer cells and immunotherapy treatment
Cancer

New hydrogel-based delivery platform exploits gasdermin-induced tumor pyroptosis to kill tumor cells

Dec. 7, 2022
Previous research has shown that cytotoxic lymphocytes rely on gasdermin-mediated pyroptosis to kill tumor cells. Pyroptosis appears to be closely involved in anticancer immune response and has therefore emerged as a promising strategy for cancer treatment. In a recently published study, scientists at the University of Wisconsin-Madison aimed to leverage gasdermin-triggered pyroptosis for antitumor immunotherapy.
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CAR T cell with implanted gene strand
Cell Therapy

Sana outlines preclinical pipeline progress following portfolio prioritization

Nov. 30, 2022
Sana Biotechnology Inc. has outlined the status of its pipeline following a portfolio prioritization. The company remains on track to file an IND this year for SC-291, the company's HIP-modified, CD19-targeted allogeneic chimeric antigen receptor (CAR) T therapy, with initial clinical data expected next year.
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