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Home » Topics » Omics » Genomics

Genomics
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DNA sequencing

Passengers, noncoding genome affect how cancers play out

Feb. 28, 2020
By Anette Breindl
Beyond every binary is a more complex reality. And so it is with driver and passenger mutations. The separation of tumor mutations into drivers and passengers underpins much progress in the development of targeted therapies.
Read More
DNA sequencing

Passengers, noncoding genome affect how cancers play out

Feb. 20, 2020
By Anette Breindl
Beyond every binary is a more complex reality. And so it is with driver and passenger mutations. The separation of tumor mutations into drivers and passengers underpins much progress in the development of targeted therapies. By looking at passenger mutations more carefully, though, researchers at Yale University have shown that passenger mutations, too, played a role in how tumors progressed.
Read More
Pan-Cancer illustration showing molecular clock in cells

Pan-Cancer Project looks closer, sees more

Feb. 11, 2020
By Nuala Moran
LONDON – The genomes of 38 different tumor types and the 47 million mutations that fostered their growth are revealed in unprecedented detail in 23 studies published in Nature and other journals on Feb. 6, 2020.
Read More
Pan-Cancer illustration showing molecular clock in cells

Pan-Cancer Project looks closer, sees more

Feb. 5, 2020
By Nuala Moran
LONDON – The genomes of 38 different tumor types and the 47 million mutations that fostered their growth are revealed in unprecedented detail in 23 studies published in Nature and other journals on Feb. 6, 2020.
Read More
Owen Smith, professor of pediatric and adolescent medicine, University College Dublin
Genomics Summit 2020

Ireland’s embrace of genomics remains tentative

Jan. 23, 2020
By Cormac Sheridan
DUBLIN – “Welcome to the conversation,” Abbvie Inc.’s head of genomic research, Howard Jacob, an early pioneer of genomics-driven medicine, told delegates during a keynote address at the Genomics Summit 2020 event Jan. 23. Ireland is very much a latecomer to that conversation and it has yet, as a country, to figure out what the shape of its contribution to the genomic era of medicine is going to be.
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DNA data illustration
J.P. Morgan Healthcare Conference

Population genetic studies set up for success, as they aim for health care and research results

Jan. 15, 2020
By Stacy Lawrence
SAN FRANCISCO – Major genetic research efforts designed to encompass millions of people globally have been setting up their infrastructure in recent years to serve both researchers and patients. This work is being done by major national initiatives, such as All of Us in the U.S. and Genomics England in the U.K., as well as by health care systems such as Intermountain and Kaiser.
Read More
Illustration of children with different skin tones
Snow White and the Seven snow white genomes

Lack of genomic diversity means actionable mutations are left undiscovered

Dec. 31, 2019
By Anette Breindl
Genome sequencing is enabling new insights into the genetic aspects of health and disease that have touched just about every aspect in biomedicine. It is also, like the “skin”-colored crayons of yore, disproportionately focused on the Caucasian segment of the population. And that is a loss for everyone.
Read More
children-skin-tones-12-31.png
Snow White and the seven snow white genomes

Lack of genomic diversity means actionable mutations are left undiscovered

Dec. 31, 2019
By Anette Breindl
Genome sequencing is enabling new insights into the genetic aspects of health and disease that have touched just about every aspect in biomedicine. It is also, like the “skin”-colored crayons of yore, disproportionately focused on the Caucasian segment of the population. And that is a loss for everyone.
Read More
DNA NGS genome sequencing

Year in Review: Promise of genomics finally impacting clinical care

Dec. 30, 2019
By Nuala Moran
LONDON – Twenty years on from sequencing of the first draft of the human genome and the associated hype, 2019 was the year that the science of genomics truly began to make an impact in health care.
Read More

Main function of Parkinson's gene is in inflammation

Oct. 7, 2019
By Anette Breindl
The leucine-repeat rich kinase 2 (Lrrk2) gets most of its attention in the context of Parkinson's disease (PD). Variants in Lrrk2 are a major cause of familial PD (though familial PD makes up only a small fraction of overall PD cases).
Read More
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